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CDK-regulated dimerization of M18BP1 on a Mis18 hexamer is necessary for CENP-A loading

Centromeres are unique chromosomal loci that promote the assembly of kinetochores, macromolecular complexes that bind spindle microtubules during mitosis. In most organisms, centromeres lack defined genetic features. Rather, they are specified epigenetically by a centromere-specific histone H3 varia...

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Detalles Bibliográficos
Autores principales: Pan, Dongqing, Klare, Kerstin, Petrovic, Arsen, Take, Annika, Walstein, Kai, Singh, Priyanka, Rondelet, Arnaud, Bird, Alexander W, Musacchio, Andrea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5245964/
https://www.ncbi.nlm.nih.gov/pubmed/28059702
http://dx.doi.org/10.7554/eLife.23352