Peripherally administered orexin improves survival of mice with endotoxin shock

Sepsis is a systemic inflammatory response to infection, accounting for the most common cause of death in intensive care units. Here, we report that peripheral administration of the hypothalamic neuropeptide orexin improves the survival of mice with lipopolysaccharide (LPS) induced endotoxin shock,...

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Detalles Bibliográficos
Autores principales: Ogawa, Yasuhiro, Irukayama-Tomobe, Yoko, Murakoshi, Nobuyuki, Kiyama, Maiko, Ishikawa, Yui, Hosokawa, Naoto, Tominaga, Hiromu, Uchida, Shuntaro, Kimura, Saki, Kanuka, Mika, Morita, Miho, Hamada, Michito, Takahashi, Satoru, Hayashi, Yu, Yanagisawa, Masashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2016
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5245965/
https://www.ncbi.nlm.nih.gov/pubmed/28035899
http://dx.doi.org/10.7554/eLife.21055

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