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Translational control of auditory imprinting and structural plasticity by eIF2α

The formation of imprinted memories during a critical period is crucial for vital behaviors, including filial attachment. Yet, little is known about the underlying molecular mechanisms. Using a combination of behavior, pharmacology, in vivo surface sensing of translation (SUnSET) and DiOlistic label...

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Autores principales: Batista, Gervasio, Johnson, Jennifer Leigh, Dominguez, Elena, Costa-Mattioli, Mauro, Pena, Jose L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5245967/
https://www.ncbi.nlm.nih.gov/pubmed/28009255
http://dx.doi.org/10.7554/eLife.17197
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author Batista, Gervasio
Johnson, Jennifer Leigh
Dominguez, Elena
Costa-Mattioli, Mauro
Pena, Jose L
author_facet Batista, Gervasio
Johnson, Jennifer Leigh
Dominguez, Elena
Costa-Mattioli, Mauro
Pena, Jose L
author_sort Batista, Gervasio
collection PubMed
description The formation of imprinted memories during a critical period is crucial for vital behaviors, including filial attachment. Yet, little is known about the underlying molecular mechanisms. Using a combination of behavior, pharmacology, in vivo surface sensing of translation (SUnSET) and DiOlistic labeling we found that, translational control by the eukaryotic translation initiation factor 2 alpha (eIF2α) bidirectionally regulates auditory but not visual imprinting and related changes in structural plasticity in chickens. Increasing phosphorylation of eIF2α (p-eIF2α) reduces translation rates and spine plasticity, and selectively impairs auditory imprinting. By contrast, inhibition of an eIF2α kinase or blocking the translational program controlled by p-eIF2α enhances auditory imprinting. Importantly, these manipulations are able to reopen the critical period. Thus, we have identified a translational control mechanism that selectively underlies auditory imprinting. Restoring translational control of eIF2α holds the promise to rejuvenate adult brain plasticity and restore learning and memory in a variety of cognitive disorders. DOI: http://dx.doi.org/10.7554/eLife.17197.001
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spelling pubmed-52459672017-01-25 Translational control of auditory imprinting and structural plasticity by eIF2α Batista, Gervasio Johnson, Jennifer Leigh Dominguez, Elena Costa-Mattioli, Mauro Pena, Jose L eLife Neuroscience The formation of imprinted memories during a critical period is crucial for vital behaviors, including filial attachment. Yet, little is known about the underlying molecular mechanisms. Using a combination of behavior, pharmacology, in vivo surface sensing of translation (SUnSET) and DiOlistic labeling we found that, translational control by the eukaryotic translation initiation factor 2 alpha (eIF2α) bidirectionally regulates auditory but not visual imprinting and related changes in structural plasticity in chickens. Increasing phosphorylation of eIF2α (p-eIF2α) reduces translation rates and spine plasticity, and selectively impairs auditory imprinting. By contrast, inhibition of an eIF2α kinase or blocking the translational program controlled by p-eIF2α enhances auditory imprinting. Importantly, these manipulations are able to reopen the critical period. Thus, we have identified a translational control mechanism that selectively underlies auditory imprinting. Restoring translational control of eIF2α holds the promise to rejuvenate adult brain plasticity and restore learning and memory in a variety of cognitive disorders. DOI: http://dx.doi.org/10.7554/eLife.17197.001 eLife Sciences Publications, Ltd 2016-12-23 /pmc/articles/PMC5245967/ /pubmed/28009255 http://dx.doi.org/10.7554/eLife.17197 Text en © 2016, Batista et al http://creativecommons.org/licenses/by/4.0/ This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Neuroscience
Batista, Gervasio
Johnson, Jennifer Leigh
Dominguez, Elena
Costa-Mattioli, Mauro
Pena, Jose L
Translational control of auditory imprinting and structural plasticity by eIF2α
title Translational control of auditory imprinting and structural plasticity by eIF2α
title_full Translational control of auditory imprinting and structural plasticity by eIF2α
title_fullStr Translational control of auditory imprinting and structural plasticity by eIF2α
title_full_unstemmed Translational control of auditory imprinting and structural plasticity by eIF2α
title_short Translational control of auditory imprinting and structural plasticity by eIF2α
title_sort translational control of auditory imprinting and structural plasticity by eif2α
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5245967/
https://www.ncbi.nlm.nih.gov/pubmed/28009255
http://dx.doi.org/10.7554/eLife.17197
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