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Translational control of auditory imprinting and structural plasticity by eIF2α
The formation of imprinted memories during a critical period is crucial for vital behaviors, including filial attachment. Yet, little is known about the underlying molecular mechanisms. Using a combination of behavior, pharmacology, in vivo surface sensing of translation (SUnSET) and DiOlistic label...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5245967/ https://www.ncbi.nlm.nih.gov/pubmed/28009255 http://dx.doi.org/10.7554/eLife.17197 |
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author | Batista, Gervasio Johnson, Jennifer Leigh Dominguez, Elena Costa-Mattioli, Mauro Pena, Jose L |
author_facet | Batista, Gervasio Johnson, Jennifer Leigh Dominguez, Elena Costa-Mattioli, Mauro Pena, Jose L |
author_sort | Batista, Gervasio |
collection | PubMed |
description | The formation of imprinted memories during a critical period is crucial for vital behaviors, including filial attachment. Yet, little is known about the underlying molecular mechanisms. Using a combination of behavior, pharmacology, in vivo surface sensing of translation (SUnSET) and DiOlistic labeling we found that, translational control by the eukaryotic translation initiation factor 2 alpha (eIF2α) bidirectionally regulates auditory but not visual imprinting and related changes in structural plasticity in chickens. Increasing phosphorylation of eIF2α (p-eIF2α) reduces translation rates and spine plasticity, and selectively impairs auditory imprinting. By contrast, inhibition of an eIF2α kinase or blocking the translational program controlled by p-eIF2α enhances auditory imprinting. Importantly, these manipulations are able to reopen the critical period. Thus, we have identified a translational control mechanism that selectively underlies auditory imprinting. Restoring translational control of eIF2α holds the promise to rejuvenate adult brain plasticity and restore learning and memory in a variety of cognitive disorders. DOI: http://dx.doi.org/10.7554/eLife.17197.001 |
format | Online Article Text |
id | pubmed-5245967 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | eLife Sciences Publications, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-52459672017-01-25 Translational control of auditory imprinting and structural plasticity by eIF2α Batista, Gervasio Johnson, Jennifer Leigh Dominguez, Elena Costa-Mattioli, Mauro Pena, Jose L eLife Neuroscience The formation of imprinted memories during a critical period is crucial for vital behaviors, including filial attachment. Yet, little is known about the underlying molecular mechanisms. Using a combination of behavior, pharmacology, in vivo surface sensing of translation (SUnSET) and DiOlistic labeling we found that, translational control by the eukaryotic translation initiation factor 2 alpha (eIF2α) bidirectionally regulates auditory but not visual imprinting and related changes in structural plasticity in chickens. Increasing phosphorylation of eIF2α (p-eIF2α) reduces translation rates and spine plasticity, and selectively impairs auditory imprinting. By contrast, inhibition of an eIF2α kinase or blocking the translational program controlled by p-eIF2α enhances auditory imprinting. Importantly, these manipulations are able to reopen the critical period. Thus, we have identified a translational control mechanism that selectively underlies auditory imprinting. Restoring translational control of eIF2α holds the promise to rejuvenate adult brain plasticity and restore learning and memory in a variety of cognitive disorders. DOI: http://dx.doi.org/10.7554/eLife.17197.001 eLife Sciences Publications, Ltd 2016-12-23 /pmc/articles/PMC5245967/ /pubmed/28009255 http://dx.doi.org/10.7554/eLife.17197 Text en © 2016, Batista et al http://creativecommons.org/licenses/by/4.0/ This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Neuroscience Batista, Gervasio Johnson, Jennifer Leigh Dominguez, Elena Costa-Mattioli, Mauro Pena, Jose L Translational control of auditory imprinting and structural plasticity by eIF2α |
title | Translational control of auditory imprinting and structural plasticity by eIF2α |
title_full | Translational control of auditory imprinting and structural plasticity by eIF2α |
title_fullStr | Translational control of auditory imprinting and structural plasticity by eIF2α |
title_full_unstemmed | Translational control of auditory imprinting and structural plasticity by eIF2α |
title_short | Translational control of auditory imprinting and structural plasticity by eIF2α |
title_sort | translational control of auditory imprinting and structural plasticity by eif2α |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5245967/ https://www.ncbi.nlm.nih.gov/pubmed/28009255 http://dx.doi.org/10.7554/eLife.17197 |
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