Sensitization of melanoma cells to alkylating agent-induced DNA damage and cell death via orchestrating oxidative stress and IKKβ inhibition

Nitrosourea represents one of the most active classes of chemotherapeutic alkylating agents for metastatic melanoma. Treatment with nitrosoureas caused severe systemic side effects which hamper its clinical use. Here, we provide pharmacological evidence that reactive oxygen species (ROS) induction a...

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Detalles Bibliográficos
Autores principales: Tse, Anfernee Kai-Wing, Chen, Ying-Jie, Fu, Xiu-Qiong, Su, Tao, Li, Ting, Guo, Hui, Zhu, Pei-Li, Kwan, Hiu-Yee, Cheng, Brian Chi-Yan, Cao, Hui-Hui, Lee, Sally Kin-Wah, Fong, Wang-Fun, Yu, Zhi-Ling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5247288/
https://www.ncbi.nlm.nih.gov/pubmed/28107677
http://dx.doi.org/10.1016/j.redox.2017.01.010

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