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Kinetically E-Selective Macrocyclic Ring-Closing Metathesis

Macrocyclic compounds are central to discovery of new drugs but their preparation is often challenging because of the energy barrier required for bringing together and fusing the two ends of an acyclic precursor(1). Ring-closing metathesis (RCM) (2,3,4) is a catalytic process that has allowed access...

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Detalles Bibliográficos
Autores principales:	Shen, Xiao, Nguyen, Thach T., Koh, Ming Joo, Xu, Dongmin, Speed, Alexander W. H., Schrock, Richard R., Hoveyda, Amir H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5247355/ https://www.ncbi.nlm.nih.gov/pubmed/28068669 http://dx.doi.org/10.1038/nature20800

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