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Drive the Car(go)s—New Modalities to Control Cargo Trafficking in Live Cells

Synaptic transmission is a fundamental molecular process underlying learning and memory. Successful synaptic transmission involves coupled interaction between electrical signals (action potentials) and chemical signals (neurotransmitters). Defective synaptic transmission has been reported in a varie...

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Autores principales: Mondal, Payel, Khamo, John S., Krishnamurthy, Vishnu V., Cai, Qi, Zhang, Kai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5247435/
https://www.ncbi.nlm.nih.gov/pubmed/28163671
http://dx.doi.org/10.3389/fnmol.2017.00004
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author Mondal, Payel
Khamo, John S.
Krishnamurthy, Vishnu V.
Cai, Qi
Zhang, Kai
author_facet Mondal, Payel
Khamo, John S.
Krishnamurthy, Vishnu V.
Cai, Qi
Zhang, Kai
author_sort Mondal, Payel
collection PubMed
description Synaptic transmission is a fundamental molecular process underlying learning and memory. Successful synaptic transmission involves coupled interaction between electrical signals (action potentials) and chemical signals (neurotransmitters). Defective synaptic transmission has been reported in a variety of neurological disorders such as Autism and Alzheimer’s disease. A large variety of macromolecules and organelles are enriched near functional synapses. Although a portion of macromolecules can be produced locally at the synapse, a large number of synaptic components especially the membrane-bound receptors and peptide neurotransmitters require active transport machinery to reach their sites of action. This spatial relocation is mediated by energy-consuming, motor protein-driven cargo trafficking. Properly regulated cargo trafficking is of fundamental importance to neuronal functions, including synaptic transmission. In this review, we discuss the molecular machinery of cargo trafficking with emphasis on new experimental strategies that enable direct modulation of cargo trafficking in live cells. These strategies promise to provide insights into a quantitative understanding of cargo trafficking, which could lead to new intervention strategies for the treatment of neurological diseases.
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spelling pubmed-52474352017-02-03 Drive the Car(go)s—New Modalities to Control Cargo Trafficking in Live Cells Mondal, Payel Khamo, John S. Krishnamurthy, Vishnu V. Cai, Qi Zhang, Kai Front Mol Neurosci Neuroscience Synaptic transmission is a fundamental molecular process underlying learning and memory. Successful synaptic transmission involves coupled interaction between electrical signals (action potentials) and chemical signals (neurotransmitters). Defective synaptic transmission has been reported in a variety of neurological disorders such as Autism and Alzheimer’s disease. A large variety of macromolecules and organelles are enriched near functional synapses. Although a portion of macromolecules can be produced locally at the synapse, a large number of synaptic components especially the membrane-bound receptors and peptide neurotransmitters require active transport machinery to reach their sites of action. This spatial relocation is mediated by energy-consuming, motor protein-driven cargo trafficking. Properly regulated cargo trafficking is of fundamental importance to neuronal functions, including synaptic transmission. In this review, we discuss the molecular machinery of cargo trafficking with emphasis on new experimental strategies that enable direct modulation of cargo trafficking in live cells. These strategies promise to provide insights into a quantitative understanding of cargo trafficking, which could lead to new intervention strategies for the treatment of neurological diseases. Frontiers Media S.A. 2017-01-20 /pmc/articles/PMC5247435/ /pubmed/28163671 http://dx.doi.org/10.3389/fnmol.2017.00004 Text en Copyright © 2017 Mondal, Khamo, Krishnamurthy, Cai and Zhang. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Mondal, Payel
Khamo, John S.
Krishnamurthy, Vishnu V.
Cai, Qi
Zhang, Kai
Drive the Car(go)s—New Modalities to Control Cargo Trafficking in Live Cells
title Drive the Car(go)s—New Modalities to Control Cargo Trafficking in Live Cells
title_full Drive the Car(go)s—New Modalities to Control Cargo Trafficking in Live Cells
title_fullStr Drive the Car(go)s—New Modalities to Control Cargo Trafficking in Live Cells
title_full_unstemmed Drive the Car(go)s—New Modalities to Control Cargo Trafficking in Live Cells
title_short Drive the Car(go)s—New Modalities to Control Cargo Trafficking in Live Cells
title_sort drive the car(go)s—new modalities to control cargo trafficking in live cells
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5247435/
https://www.ncbi.nlm.nih.gov/pubmed/28163671
http://dx.doi.org/10.3389/fnmol.2017.00004
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