APP Deletion Accounts for Age-Dependent Changes in the Bioenergetic Metabolism and in Hyperphosphorylated CaMKII at Stimulated Hippocampal Presynaptic Active Zones

Synaptic release sites are characterized by exocytosis-competent synaptic vesicles tightly anchored to the presynaptic active zone (PAZ) whose proteome orchestrates the fast signaling events involved in synaptic vesicle cycle and plasticity. Allocation of the amyloid precursor protein (APP) to the P...

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Detalles Bibliográficos
Autores principales: Laßek, Melanie, Weingarten, Jens, Wegner, Martin, Neupärtl, Moritz, Array, Tabiwang N., Harde, Eva, Beckert, Benedikt, Golghalyani, Vahid, Ackermann, Jörg, Koch, Ina, Müller, Ulrike C., Karas, Michael, Acker-Palmer, Amparo, Volknandt, Walter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5247443/
https://www.ncbi.nlm.nih.gov/pubmed/28163681
http://dx.doi.org/10.3389/fnsyn.2017.00001

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