Contribution of classical end-joining to PTEN inactivation in p53-mediated glioblastoma formation and drug-resistant survival

DNA repair gene defects are found in virtually all human glioblastomas, but the genetic evidence for a direct role remains lacking. Here we demonstrate that combined inactivation of the XRCC4 non-homologous end-joining (NHEJ) DNA repair gene and p53 efficiently induces brain tumours with hallmark ch...

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Detalles Bibliográficos
Autores principales: Kang, Youn-Jung, Balter, Barbara, Csizmadia, Eva, Haas, Brian, Sharma, Himanshu, Bronson, Roderick, Yan, Catherine T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5247582/
https://www.ncbi.nlm.nih.gov/pubmed/28094268
http://dx.doi.org/10.1038/ncomms14013

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