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The Production and Utilization of GDP-glucose in the Biosynthesis of Trehalose 6-Phosphate by Streptomyces venezuelae

Trehalose-6-phosphate synthase OtsA from streptomycetes is unusual in that it uses GDP-glucose as the donor substrate rather than the more commonly used UDP-glucose. We now confirm that OtsA from Streptomyces venezuelae has such a preference for GDP-glucose and can utilize ADP-glucose to some extent...

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Detalles Bibliográficos
Autores principales:	Asención Diez, Matías D., Miah, Farzana, Stevenson, Clare E. M., Lawson, David M., Iglesias, Alberto A., Bornemann, Stephen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2017
Materias:	Enzymology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5247666/ https://www.ncbi.nlm.nih.gov/pubmed/27903647 http://dx.doi.org/10.1074/jbc.M116.758664

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