In vivo detection of cucurbit[6]uril, a hyperpolarized xenon contrast agent for a xenon magnetic resonance imaging biosensor

The Hyperpolarized gas Chemical Exchange Saturation Transfer (HyperCEST) Magnetic Resonance (MR) technique has the potential to increase the sensitivity of a hyperpolarized xenon-129 MRI contrast agent. Signal enhancement is accomplished by selectively depolarizing the xenon within a cage molecule w...

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Autores principales: Hane, Francis T., Li, Tao, Smylie, Peter, Pellizzari, Raiili M., Plata, Jennifer A., DeBoef, Brenton, Albert, Mitchell S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5247686/
https://www.ncbi.nlm.nih.gov/pubmed/28106110
http://dx.doi.org/10.1038/srep41027
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author Hane, Francis T.
Li, Tao
Smylie, Peter
Pellizzari, Raiili M.
Plata, Jennifer A.
DeBoef, Brenton
Albert, Mitchell S.
author_facet Hane, Francis T.
Li, Tao
Smylie, Peter
Pellizzari, Raiili M.
Plata, Jennifer A.
DeBoef, Brenton
Albert, Mitchell S.
author_sort Hane, Francis T.
collection PubMed
description The Hyperpolarized gas Chemical Exchange Saturation Transfer (HyperCEST) Magnetic Resonance (MR) technique has the potential to increase the sensitivity of a hyperpolarized xenon-129 MRI contrast agent. Signal enhancement is accomplished by selectively depolarizing the xenon within a cage molecule which, upon exchange, reduces the signal in the dissolved phase pool. Herein we demonstrate the in vivo detection of the cucurbit[6]uril (CB6) contrast agent within the vasculature of a living rat. Our work may be used as a stepping stone towards using the HyperCEST technique as a molecular imaging modality.
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spelling pubmed-52476862017-01-23 In vivo detection of cucurbit[6]uril, a hyperpolarized xenon contrast agent for a xenon magnetic resonance imaging biosensor Hane, Francis T. Li, Tao Smylie, Peter Pellizzari, Raiili M. Plata, Jennifer A. DeBoef, Brenton Albert, Mitchell S. Sci Rep Article The Hyperpolarized gas Chemical Exchange Saturation Transfer (HyperCEST) Magnetic Resonance (MR) technique has the potential to increase the sensitivity of a hyperpolarized xenon-129 MRI contrast agent. Signal enhancement is accomplished by selectively depolarizing the xenon within a cage molecule which, upon exchange, reduces the signal in the dissolved phase pool. Herein we demonstrate the in vivo detection of the cucurbit[6]uril (CB6) contrast agent within the vasculature of a living rat. Our work may be used as a stepping stone towards using the HyperCEST technique as a molecular imaging modality. Nature Publishing Group 2017-01-20 /pmc/articles/PMC5247686/ /pubmed/28106110 http://dx.doi.org/10.1038/srep41027 Text en Copyright © 2017, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Hane, Francis T.
Li, Tao
Smylie, Peter
Pellizzari, Raiili M.
Plata, Jennifer A.
DeBoef, Brenton
Albert, Mitchell S.
In vivo detection of cucurbit[6]uril, a hyperpolarized xenon contrast agent for a xenon magnetic resonance imaging biosensor
title In vivo detection of cucurbit[6]uril, a hyperpolarized xenon contrast agent for a xenon magnetic resonance imaging biosensor
title_full In vivo detection of cucurbit[6]uril, a hyperpolarized xenon contrast agent for a xenon magnetic resonance imaging biosensor
title_fullStr In vivo detection of cucurbit[6]uril, a hyperpolarized xenon contrast agent for a xenon magnetic resonance imaging biosensor
title_full_unstemmed In vivo detection of cucurbit[6]uril, a hyperpolarized xenon contrast agent for a xenon magnetic resonance imaging biosensor
title_short In vivo detection of cucurbit[6]uril, a hyperpolarized xenon contrast agent for a xenon magnetic resonance imaging biosensor
title_sort in vivo detection of cucurbit[6]uril, a hyperpolarized xenon contrast agent for a xenon magnetic resonance imaging biosensor
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5247686/
https://www.ncbi.nlm.nih.gov/pubmed/28106110
http://dx.doi.org/10.1038/srep41027
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