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Altered motion repulsion in Alzheimer’s disease
Recent research in Alzheimer’s disease (AD) indicates that perceptual impairments may occur before the onset of cognitive declines, and can thus serve as an early noninvasive indicator for AD. In this study, we focused on visual motion processing and explored whether AD induces changes in the proper...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5247699/ https://www.ncbi.nlm.nih.gov/pubmed/28106153 http://dx.doi.org/10.1038/srep40946 |
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author | Li, Yan Guo, Shougang Wang, Yongxiang Chen, Huan |
author_facet | Li, Yan Guo, Shougang Wang, Yongxiang Chen, Huan |
author_sort | Li, Yan |
collection | PubMed |
description | Recent research in Alzheimer’s disease (AD) indicates that perceptual impairments may occur before the onset of cognitive declines, and can thus serve as an early noninvasive indicator for AD. In this study, we focused on visual motion processing and explored whether AD induces changes in the properties of direction repulsion between two competing motions. We used random dot kinematograms (RDKs) and measured the magnitudes of direction repulsion between two overlapping RDKs moving different directions in three groups of participants: an AD group, an age-matched old control group, and a young control group. We showed that motion direction repulsion was significantly weaker in AD patients as comparing to both healthy controls. More importantly, we found that the magnitude of motion repulsion was predictive of the assessment of clinical severity in the AD group. Our results implicate that AD pathology is associated with altered neural functions in visual cortical areas and that motion repulsion deficit is a behavioral biomarker for the tracking of AD development. |
format | Online Article Text |
id | pubmed-5247699 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-52476992017-01-23 Altered motion repulsion in Alzheimer’s disease Li, Yan Guo, Shougang Wang, Yongxiang Chen, Huan Sci Rep Article Recent research in Alzheimer’s disease (AD) indicates that perceptual impairments may occur before the onset of cognitive declines, and can thus serve as an early noninvasive indicator for AD. In this study, we focused on visual motion processing and explored whether AD induces changes in the properties of direction repulsion between two competing motions. We used random dot kinematograms (RDKs) and measured the magnitudes of direction repulsion between two overlapping RDKs moving different directions in three groups of participants: an AD group, an age-matched old control group, and a young control group. We showed that motion direction repulsion was significantly weaker in AD patients as comparing to both healthy controls. More importantly, we found that the magnitude of motion repulsion was predictive of the assessment of clinical severity in the AD group. Our results implicate that AD pathology is associated with altered neural functions in visual cortical areas and that motion repulsion deficit is a behavioral biomarker for the tracking of AD development. Nature Publishing Group 2017-01-20 /pmc/articles/PMC5247699/ /pubmed/28106153 http://dx.doi.org/10.1038/srep40946 Text en Copyright © 2017, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Li, Yan Guo, Shougang Wang, Yongxiang Chen, Huan Altered motion repulsion in Alzheimer’s disease |
title | Altered motion repulsion in Alzheimer’s disease |
title_full | Altered motion repulsion in Alzheimer’s disease |
title_fullStr | Altered motion repulsion in Alzheimer’s disease |
title_full_unstemmed | Altered motion repulsion in Alzheimer’s disease |
title_short | Altered motion repulsion in Alzheimer’s disease |
title_sort | altered motion repulsion in alzheimer’s disease |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5247699/ https://www.ncbi.nlm.nih.gov/pubmed/28106153 http://dx.doi.org/10.1038/srep40946 |
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