Formation of diverse polycyclic spirooxindoles via three-component reaction of isoquinolinium salts, isatins and malononitrile

The triethylamine promoted three-component reaction of N-(4-nitrobenzyl), N-ethoxycarbonylmethylisoquinolinium bromide, isatins and malononitrile in ethanol afforded spiro[indoline-3,2′-pyrrolo[2,1-a]isoquinolines] in good yields and with high diastereoselectivity. The similar reaction of N-cyanomet...

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Detalles Bibliográficos
Autores principales: Sun, Jing, Shen, Guo-liang, Huang, Ying, Yan, Chao-Guo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5247726/
https://www.ncbi.nlm.nih.gov/pubmed/28106130
http://dx.doi.org/10.1038/srep41024

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5247726/
https://www.ncbi.nlm.nih.gov/pubmed/28106130
http://dx.doi.org/10.1038/srep41024

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