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Current Challenges toward In Vitro Cellular Validation of Inorganic Nanoparticles

[Image: see text] An impressive development has been achieved toward the production of well-defined “smart” inorganic nanoparticles, in which the physicochemical properties can be controlled and predicted to a high degree of accuracy. Nanoparticle design is indeed highly advanced, multimodal and mul...

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Autores principales: Henriksen-Lacey, Malou, Carregal-Romero, Susana, Liz-Marzán, Luis M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2016
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5247775/
https://www.ncbi.nlm.nih.gov/pubmed/27709892
http://dx.doi.org/10.1021/acs.bioconjchem.6b00514
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author Henriksen-Lacey, Malou
Carregal-Romero, Susana
Liz-Marzán, Luis M.
author_facet Henriksen-Lacey, Malou
Carregal-Romero, Susana
Liz-Marzán, Luis M.
author_sort Henriksen-Lacey, Malou
collection PubMed
description [Image: see text] An impressive development has been achieved toward the production of well-defined “smart” inorganic nanoparticles, in which the physicochemical properties can be controlled and predicted to a high degree of accuracy. Nanoparticle design is indeed highly advanced, multimodal and multitargeting being the norm, yet we do not fully understand the obstacles that nanoparticles face when used in vivo. Increased cooperation between chemists and biochemists, immunologists and physicists, has allowed us to think outside the box, and we are slowly starting to understand the interactions that nanoparticles undergo under more realistic situations. Importantly, such an understanding involves awareness about the limitations when assessing the influence of such inorganic nanoparticles on biological entities and vice versa, as well as the development of new validation strategies.
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spelling pubmed-52477752017-01-23 Current Challenges toward In Vitro Cellular Validation of Inorganic Nanoparticles Henriksen-Lacey, Malou Carregal-Romero, Susana Liz-Marzán, Luis M. Bioconjug Chem [Image: see text] An impressive development has been achieved toward the production of well-defined “smart” inorganic nanoparticles, in which the physicochemical properties can be controlled and predicted to a high degree of accuracy. Nanoparticle design is indeed highly advanced, multimodal and multitargeting being the norm, yet we do not fully understand the obstacles that nanoparticles face when used in vivo. Increased cooperation between chemists and biochemists, immunologists and physicists, has allowed us to think outside the box, and we are slowly starting to understand the interactions that nanoparticles undergo under more realistic situations. Importantly, such an understanding involves awareness about the limitations when assessing the influence of such inorganic nanoparticles on biological entities and vice versa, as well as the development of new validation strategies. American Chemical Society 2016-10-06 2017-01-18 /pmc/articles/PMC5247775/ /pubmed/27709892 http://dx.doi.org/10.1021/acs.bioconjchem.6b00514 Text en Copyright © 2016 American Chemical Society This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
spellingShingle Henriksen-Lacey, Malou
Carregal-Romero, Susana
Liz-Marzán, Luis M.
Current Challenges toward In Vitro Cellular Validation of Inorganic Nanoparticles
title Current Challenges toward In Vitro Cellular Validation of Inorganic Nanoparticles
title_full Current Challenges toward In Vitro Cellular Validation of Inorganic Nanoparticles
title_fullStr Current Challenges toward In Vitro Cellular Validation of Inorganic Nanoparticles
title_full_unstemmed Current Challenges toward In Vitro Cellular Validation of Inorganic Nanoparticles
title_short Current Challenges toward In Vitro Cellular Validation of Inorganic Nanoparticles
title_sort current challenges toward in vitro cellular validation of inorganic nanoparticles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5247775/
https://www.ncbi.nlm.nih.gov/pubmed/27709892
http://dx.doi.org/10.1021/acs.bioconjchem.6b00514
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