Lineage-specific duplication of amphioxus retinoic acid degrading enzymes (CYP26) resulted in sub-functionalization of patterning and homeostatic roles

BACKGROUND: During embryogenesis, tight regulation of retinoic acid (RA) availability is fundamental for normal development. In parallel to RA synthesis, a negative feedback loop controlled by RA catabolizing enzymes of the cytochrome P450 subfamily 26 (CYP26) is crucial. In vertebrates, the functio...

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Detalles Bibliográficos
Autores principales: Carvalho, João E., Theodosiou, Maria, Chen, Jie, Chevret, Pascale, Alvarez, Susana, De Lera, Angel R., Laudet, Vincent, Croce, Jenifer C., Schubert, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5247814/
https://www.ncbi.nlm.nih.gov/pubmed/28103795
http://dx.doi.org/10.1186/s12862-016-0863-1

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