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Accelerated antidepressant response to lithium augmentation of imipramine
BACKGROUND: Treatment of depressive episode often poses a challenge. Although there are numerous medicines available for its treatment but they all have a lag period of 2–3 weeks before they start showing their result. AIM: The aim of the present study was to test the hypothesis that an initial lith...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5248426/ https://www.ncbi.nlm.nih.gov/pubmed/28163414 http://dx.doi.org/10.4103/0972-6748.196057 |
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author | Saini, Rajiv Raju, M. S. V. K. Chaudhury, Suprakash Srivastava, Kalpana |
author_facet | Saini, Rajiv Raju, M. S. V. K. Chaudhury, Suprakash Srivastava, Kalpana |
author_sort | Saini, Rajiv |
collection | PubMed |
description | BACKGROUND: Treatment of depressive episode often poses a challenge. Although there are numerous medicines available for its treatment but they all have a lag period of 2–3 weeks before they start showing their result. AIM: The aim of the present study was to test the hypothesis that an initial lithium-tricyclic antidepressant (TCA) combination has a quicker and better antidepressant effect than standard TCA treatment in unipolar depression. MATERIALS AND METHODS: Twenty unipolar depressed inpatients under lithium-TCA treatment were compared with twenty patients with similar diagnosis treated with TCA-placebo combination. The duration of the study was 4 weeks under double-blind conditions. RESULTS: Initial lithium-TCA treatment reduced depressive symptoms significantly more than TCA alone. The difference was evident from 1(st) week onward and persisted at 4 weeks. CONCLUSION: Lithium augmentation of TCA at the outset offers a strategy to reduce the lag period of antidepressant action. The choice can be made for those patients who are likely to benefit from long-term prophylaxis. |
format | Online Article Text |
id | pubmed-5248426 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-52484262017-02-03 Accelerated antidepressant response to lithium augmentation of imipramine Saini, Rajiv Raju, M. S. V. K. Chaudhury, Suprakash Srivastava, Kalpana Ind Psychiatry J Original Article BACKGROUND: Treatment of depressive episode often poses a challenge. Although there are numerous medicines available for its treatment but they all have a lag period of 2–3 weeks before they start showing their result. AIM: The aim of the present study was to test the hypothesis that an initial lithium-tricyclic antidepressant (TCA) combination has a quicker and better antidepressant effect than standard TCA treatment in unipolar depression. MATERIALS AND METHODS: Twenty unipolar depressed inpatients under lithium-TCA treatment were compared with twenty patients with similar diagnosis treated with TCA-placebo combination. The duration of the study was 4 weeks under double-blind conditions. RESULTS: Initial lithium-TCA treatment reduced depressive symptoms significantly more than TCA alone. The difference was evident from 1(st) week onward and persisted at 4 weeks. CONCLUSION: Lithium augmentation of TCA at the outset offers a strategy to reduce the lag period of antidepressant action. The choice can be made for those patients who are likely to benefit from long-term prophylaxis. Medknow Publications & Media Pvt Ltd 2016 /pmc/articles/PMC5248426/ /pubmed/28163414 http://dx.doi.org/10.4103/0972-6748.196057 Text en Copyright: © Industrial Psychiatry Journal http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. |
spellingShingle | Original Article Saini, Rajiv Raju, M. S. V. K. Chaudhury, Suprakash Srivastava, Kalpana Accelerated antidepressant response to lithium augmentation of imipramine |
title | Accelerated antidepressant response to lithium augmentation of imipramine |
title_full | Accelerated antidepressant response to lithium augmentation of imipramine |
title_fullStr | Accelerated antidepressant response to lithium augmentation of imipramine |
title_full_unstemmed | Accelerated antidepressant response to lithium augmentation of imipramine |
title_short | Accelerated antidepressant response to lithium augmentation of imipramine |
title_sort | accelerated antidepressant response to lithium augmentation of imipramine |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5248426/ https://www.ncbi.nlm.nih.gov/pubmed/28163414 http://dx.doi.org/10.4103/0972-6748.196057 |
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