Photoreceptor protection via blockade of BET epigenetic readers in a murine model of inherited retinal degeneration

BACKGROUND: The bromodomain and extraterminal domain (BET) family proteins (BET2, BET3, and BET4) “read” (bind) histone acetylation marks via two distinct bromodomains (Brom1 and Brom2) facilitating transcriptional activation. These epigenetic “readers” play crucial roles in pathogenic processes suc...

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Detalles Bibliográficos
Autores principales: Zhao, Lei, Li, Jun, Fu, Yingmei, Zhang, Mengxue, Wang, Bowen, Ouellette, Jonathan, Shahi, Pawan K., Pattnaik, Bikash R., Watters, Jyoti J., Wong, Wai T., Guo, Lian-Wang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5248448/
https://www.ncbi.nlm.nih.gov/pubmed/28103888
http://dx.doi.org/10.1186/s12974-016-0775-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5248448/
https://www.ncbi.nlm.nih.gov/pubmed/28103888
http://dx.doi.org/10.1186/s12974-016-0775-4

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