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Genetic structure in the Sherpa and neighboring Nepalese populations
BACKGROUND: We set out to describe the fine-scale population structure across the Eastern region of Nepal. To date there is relatively little known about the genetic structure of the Sherpa residing in Nepal and their genetic relationship with the Nepalese. We assembled dense genotype data from a to...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5248489/ https://www.ncbi.nlm.nih.gov/pubmed/28103797 http://dx.doi.org/10.1186/s12864-016-3469-5 |
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author | Cole, Amy M. Cox, Sean Jeong, Choongwon Petousi, Nayia Aryal, Dhana R. Droma, Yunden Hanaoka, Masayuki Ota, Masao Kobayashi, Nobumitsu Gasparini, Paolo Montgomery, Hugh Robbins, Peter Di Rienzo, Anna Cavalleri, Gianpiero L. |
author_facet | Cole, Amy M. Cox, Sean Jeong, Choongwon Petousi, Nayia Aryal, Dhana R. Droma, Yunden Hanaoka, Masayuki Ota, Masao Kobayashi, Nobumitsu Gasparini, Paolo Montgomery, Hugh Robbins, Peter Di Rienzo, Anna Cavalleri, Gianpiero L. |
author_sort | Cole, Amy M. |
collection | PubMed |
description | BACKGROUND: We set out to describe the fine-scale population structure across the Eastern region of Nepal. To date there is relatively little known about the genetic structure of the Sherpa residing in Nepal and their genetic relationship with the Nepalese. We assembled dense genotype data from a total of 1245 individuals representing Nepal and a variety of different populations resident across the greater Himalayan region including Tibet, China, India, Pakistan, Kazakhstan, Uzbekistan, Tajikistan and Kirghizstan. We performed analysis of principal components, admixture and homozygosity. RESULTS: We identified clear substructure across populations resident in the Himalayan arc, with genetic structure broadly mirroring geographical features of the region. Ethnic subgroups within Nepal show distinct genetic structure, on both admixture and principal component analysis. We detected differential proportions of ancestry from northern Himalayan populations across Nepalese subgroups, with the Nepalese Rai, Magar and Tamang carrying the greatest proportions of Tibetan ancestry. CONCLUSIONS: We show that populations dwelling on the Himalayan plateau have had a clear impact on the Northern Indian gene pool. We illustrate how the Sherpa are a remarkably isolated population, with little gene flow from surrounding Nepalese populations. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12864-016-3469-5) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-5248489 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-52484892017-01-25 Genetic structure in the Sherpa and neighboring Nepalese populations Cole, Amy M. Cox, Sean Jeong, Choongwon Petousi, Nayia Aryal, Dhana R. Droma, Yunden Hanaoka, Masayuki Ota, Masao Kobayashi, Nobumitsu Gasparini, Paolo Montgomery, Hugh Robbins, Peter Di Rienzo, Anna Cavalleri, Gianpiero L. BMC Genomics Research Article BACKGROUND: We set out to describe the fine-scale population structure across the Eastern region of Nepal. To date there is relatively little known about the genetic structure of the Sherpa residing in Nepal and their genetic relationship with the Nepalese. We assembled dense genotype data from a total of 1245 individuals representing Nepal and a variety of different populations resident across the greater Himalayan region including Tibet, China, India, Pakistan, Kazakhstan, Uzbekistan, Tajikistan and Kirghizstan. We performed analysis of principal components, admixture and homozygosity. RESULTS: We identified clear substructure across populations resident in the Himalayan arc, with genetic structure broadly mirroring geographical features of the region. Ethnic subgroups within Nepal show distinct genetic structure, on both admixture and principal component analysis. We detected differential proportions of ancestry from northern Himalayan populations across Nepalese subgroups, with the Nepalese Rai, Magar and Tamang carrying the greatest proportions of Tibetan ancestry. CONCLUSIONS: We show that populations dwelling on the Himalayan plateau have had a clear impact on the Northern Indian gene pool. We illustrate how the Sherpa are a remarkably isolated population, with little gene flow from surrounding Nepalese populations. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12864-016-3469-5) contains supplementary material, which is available to authorized users. BioMed Central 2017-01-19 /pmc/articles/PMC5248489/ /pubmed/28103797 http://dx.doi.org/10.1186/s12864-016-3469-5 Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Cole, Amy M. Cox, Sean Jeong, Choongwon Petousi, Nayia Aryal, Dhana R. Droma, Yunden Hanaoka, Masayuki Ota, Masao Kobayashi, Nobumitsu Gasparini, Paolo Montgomery, Hugh Robbins, Peter Di Rienzo, Anna Cavalleri, Gianpiero L. Genetic structure in the Sherpa and neighboring Nepalese populations |
title | Genetic structure in the Sherpa and neighboring Nepalese populations |
title_full | Genetic structure in the Sherpa and neighboring Nepalese populations |
title_fullStr | Genetic structure in the Sherpa and neighboring Nepalese populations |
title_full_unstemmed | Genetic structure in the Sherpa and neighboring Nepalese populations |
title_short | Genetic structure in the Sherpa and neighboring Nepalese populations |
title_sort | genetic structure in the sherpa and neighboring nepalese populations |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5248489/ https://www.ncbi.nlm.nih.gov/pubmed/28103797 http://dx.doi.org/10.1186/s12864-016-3469-5 |
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