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Emergency use of uridine triacetate for the prevention and treatment of life‐threatening 5‐fluorouracil and capecitabine toxicity

BACKGROUND: Increased susceptibility to 5‐fluorouracil (5‐FU)/capecitabine can lead to rapidly occurring toxicity caused by impaired clearance, dihydropyrimidine dehydrogenase deficiency, and other genetic variations in the enzymes that metabolize 5‐FU. Life‐threatening 5‐FU overdoses occur because...

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Detalles Bibliográficos
Autores principales:	Ma, Wen Wee, Saif, Muhammad Wasif, El‐Rayes, Bassel F., Fakih, Marwan G., Cartwright, Thomas H., Posey, James A., King, Thomas R., von Borstel, Reid W., Bamat, Michael K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2016
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5248610/ https://www.ncbi.nlm.nih.gov/pubmed/27622829 http://dx.doi.org/10.1002/cncr.30321

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