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Vitamin D supplementation and its influence on muscle strength and mobility in community‐dwelling older persons: a systematic review and meta‐analysis

BACKGROUND: It has been suggested that vitamin D status or supplementation is important for maintaining or improving muscle strength and mobility in older adults. The study results, however, do not provide consistent results. We therefore aimed to summarise the available evidence systematically, inc...

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Autores principales: Rosendahl‐Riise, H., Spielau, U., Ranhoff, A. H., Gudbrandsen, O. A., Dierkes, J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5248635/
https://www.ncbi.nlm.nih.gov/pubmed/27460044
http://dx.doi.org/10.1111/jhn.12394
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author Rosendahl‐Riise, H.
Spielau, U.
Ranhoff, A. H.
Gudbrandsen, O. A.
Dierkes, J.
author_facet Rosendahl‐Riise, H.
Spielau, U.
Ranhoff, A. H.
Gudbrandsen, O. A.
Dierkes, J.
author_sort Rosendahl‐Riise, H.
collection PubMed
description BACKGROUND: It has been suggested that vitamin D status or supplementation is important for maintaining or improving muscle strength and mobility in older adults. The study results, however, do not provide consistent results. We therefore aimed to summarise the available evidence systematically, including only studies conducted in community‐dwelling older persons. METHODS: A systematic search of the literature was performed in April of 2016. The systematic review includes studies that used vitamin D with or without calcium supplementation as the exposure variable and various measurements of muscle strength and mobility. The meta‐analysis was limited to studies using hand grip strength (HGS) and timed‐up‐and‐go test as the outcome variables. RESULTS: A total of 15 studies out of 2408 articles from the literature search were included in the systematic review, providing 2866 participants above the age of 65 years. In the majority of studies, no improvement in muscle strength and mobility was observed after administration of vitamin D with or without calcium supplements. In the meta‐analysis, we observed a nonsignificant change in HGS [+0.2 kg (95% confidence interval = −0.25 to 0.7 kg; seven studies)] and a small, significant increase in the timed‐up‐and‐go test [0.3 s (95% confidence interval = 0.1 to 0.5 s; five studies)] after vitamin D supplementation. The meta‐analyses showed a high degree of heterogeneity between the studies. CONCLUSIONS: In conclusion, we observed no improvement in muscle strength after the administration of vitamin D with or without calcium supplements. We did find a small but significant deterioration of mobility. However, this is based on a limited number of studies and participants.
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spelling pubmed-52486352017-02-03 Vitamin D supplementation and its influence on muscle strength and mobility in community‐dwelling older persons: a systematic review and meta‐analysis Rosendahl‐Riise, H. Spielau, U. Ranhoff, A. H. Gudbrandsen, O. A. Dierkes, J. J Hum Nutr Diet Older People BACKGROUND: It has been suggested that vitamin D status or supplementation is important for maintaining or improving muscle strength and mobility in older adults. The study results, however, do not provide consistent results. We therefore aimed to summarise the available evidence systematically, including only studies conducted in community‐dwelling older persons. METHODS: A systematic search of the literature was performed in April of 2016. The systematic review includes studies that used vitamin D with or without calcium supplementation as the exposure variable and various measurements of muscle strength and mobility. The meta‐analysis was limited to studies using hand grip strength (HGS) and timed‐up‐and‐go test as the outcome variables. RESULTS: A total of 15 studies out of 2408 articles from the literature search were included in the systematic review, providing 2866 participants above the age of 65 years. In the majority of studies, no improvement in muscle strength and mobility was observed after administration of vitamin D with or without calcium supplements. In the meta‐analysis, we observed a nonsignificant change in HGS [+0.2 kg (95% confidence interval = −0.25 to 0.7 kg; seven studies)] and a small, significant increase in the timed‐up‐and‐go test [0.3 s (95% confidence interval = 0.1 to 0.5 s; five studies)] after vitamin D supplementation. The meta‐analyses showed a high degree of heterogeneity between the studies. CONCLUSIONS: In conclusion, we observed no improvement in muscle strength after the administration of vitamin D with or without calcium supplements. We did find a small but significant deterioration of mobility. However, this is based on a limited number of studies and participants. John Wiley and Sons Inc. 2016-07-27 2017-02 /pmc/articles/PMC5248635/ /pubmed/27460044 http://dx.doi.org/10.1111/jhn.12394 Text en © 2016 The Authors Journal of Human Nutrition and Dietetics published by John Wiley & Sons Ltd on behalf of British Dietetic Association This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Older People
Rosendahl‐Riise, H.
Spielau, U.
Ranhoff, A. H.
Gudbrandsen, O. A.
Dierkes, J.
Vitamin D supplementation and its influence on muscle strength and mobility in community‐dwelling older persons: a systematic review and meta‐analysis
title Vitamin D supplementation and its influence on muscle strength and mobility in community‐dwelling older persons: a systematic review and meta‐analysis
title_full Vitamin D supplementation and its influence on muscle strength and mobility in community‐dwelling older persons: a systematic review and meta‐analysis
title_fullStr Vitamin D supplementation and its influence on muscle strength and mobility in community‐dwelling older persons: a systematic review and meta‐analysis
title_full_unstemmed Vitamin D supplementation and its influence on muscle strength and mobility in community‐dwelling older persons: a systematic review and meta‐analysis
title_short Vitamin D supplementation and its influence on muscle strength and mobility in community‐dwelling older persons: a systematic review and meta‐analysis
title_sort vitamin d supplementation and its influence on muscle strength and mobility in community‐dwelling older persons: a systematic review and meta‐analysis
topic Older People
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5248635/
https://www.ncbi.nlm.nih.gov/pubmed/27460044
http://dx.doi.org/10.1111/jhn.12394
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