Cargando…

Anti-MrkA Monoclonal Antibodies Reveal Distinct Structural and Antigenic Features of MrkA

Antibody therapy against antibiotics resistant Klebsiella pneumoniae infections represents a promising strategy, the success of which depends critically on the ability to identify appropriate antibody targets. Using a target-agnostic strategy, we recently discovered MrkA as a potential antibody targ...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Qun, Chen, Yan, Cvitkovic, Romana, Pennini, Meghan E., Chang, Chew shun, Pelletier, Mark, Bonnell, Jessica, Koksal, Adem C., Wu, Herren, Dall’Acqua, William F., Stover, C. Kendall, Xiao, Xiaodong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5249199/ https://www.ncbi.nlm.nih.gov/pubmed/28107434 http://dx.doi.org/10.1371/journal.pone.0170529

Ejemplares similares

Transcriptional Activation of the mrkA Promoter of the Klebsiella pneumoniae Type 3 Fimbrial Operon by the c-di-GMP-Dependent MrkH Protein
por: Yang, Ji, et al.
Publicado: (2013)

Association between Presence of RmpA, MrkA and MrkD Genes and Antibiotic Resistance in Clinical Klebsiella pneumoniae Isolates from Hospitals in Tehran, Iran
por: Bakhtiari, Ronak, et al.
Publicado: (2021)

Observations of Mrk 421 with the MAGIC Telescope
por: Mazin, D
Publicado: (2005)

Additional regulatory activities of MrkH for the transcriptional expression of the Klebsiella pneumoniae mrk genes: Antagonist of H-NS and repressor
por: Ares, Miguel A., et al.
Publicado: (2017)

High-level expression of MRK 16 and MRK 20 murine monoclonal antibody-define proteins (170,000-180,000 P-glycoprotein and 85,000 protein) in leukaemias and malignant lymphomas.
por: Sugawara, I., et al.
Publicado: (1989)

Simultaneous Multi-wavelength Variability of the TeV Blazar Mrk 421
por: Gupta, A C
Publicado: (2005)

Molecular basis for isoform-selective inhibition of presenilin-1 by MRK-560
por: Guo, Xuefei, et al.
Publicado: (2022)

Enhancement of Reversing Effect of Cyclosporin A on Vincristine Resistance by Anti‐P‐glycoprotein Monoclonal Antibody MRK‐16
por: Naito, Mikihiko, et al.
Publicado: (1993)

Specialized Localization of P‐Glycoprotein Recognized by MRK 16 Monoclonal Antibody in Endothelial Cells of the Brain and the Spinal Cord
por: Sugawara, Isamu, et al.
Publicado: (1990)

Multidrug Resistance in Cultured Human Leukemia and Lymphoma Cell Lines Detected by a Monoclonal Antibody, MRK16
por: Ishida, Yasushi, et al.
Publicado: (1989)

Regulation of cilium length and intraflagellar transport by the MAP kinases MAK, MRK, and MOK
por: Jansen, G, et al.
Publicado: (2012)

The PilZ domain of MrkH represents a novel DNA binding motif
por: Wang, Feng, et al.
Publicado: (2016)

Novel Insights into MSK1 Phosphorylation by MRKβ in Intracerebral Hemorrhage-Induced Neuronal Apoptosis
por: Gong, Peipei, et al.
Publicado: (2019)

Further Characterization of the Human Adrenal‐derived P‐GIycoprotein Recognized by Monoclonal Antibody MRK 16 Reacting with Only Human P‐Glycoprotein
por: Sugawara, Isamu, et al.
Publicado: (1989)

Cellular and Tissue Distribution of MRK20 Murine Monoclonal Antibody‐defined 85‐kDa Protein in Adriamycin‐resistant Cancer Cell Lines
por: Sugawara, Isamu, et al.
Publicado: (1988)

A Novel Multidrug Resistance in Cultured Leukemia and Lymphoma Cells Detected by a Monoclonal Antibody to 85‐kDa Protein, MRK20
por: Ohtsu, Tomoko, et al.
Publicado: (1989)

The novel leucine-rich repeat receptor-like kinase MRK1 regulates resistance to multiple stresses in tomato
por: Ma, Qiaomei, et al.
Publicado: (2022)

Genome-wide end-sequenced BAC resources for the NOD/MrkTac(☆) and NOD/ShiLtJ(☆☆) mouse genomes
por: Steward, Charles A., et al.
Publicado: (2010)

Predictors of HVTN 503 MRK-AD5 HIV-1 gag/pol/nef Vaccine Induced Immune Responses
por: Hopkins, Kathryn L., et al.
Publicado: (2014)

Correction: The novel leucine-rich repeat receptor-like kinase MRK1 regulates resistance to multiple stresses in tomato
por: Ma, Qiaomei, et al.
Publicado: (2022)

Unravelling the complex behavior of Mrk 421 with simultaneous X-ray and VHE observations during an extreme flaring activity in April 2013
por: Acciari, V.A., et al.
Publicado: (2020)

Downregulation of mapk/mak/mrk overlapping kinase 1 in peripheral blood mononuclear cells of pediatric patients with type 1 diabetes mellitus
por: Sopić, Miron, et al.
Publicado: (2022)

Expression Behavior of 85‐kDa Membrane Protein in Adriamycin‐resistant Tumor Cells and the Inhibition of Human Tumor Growth in Athymic Mice by MRK‐20 Monoclonal Antibody against the Protein
por: Ishii, Shigetaka, et al.
Publicado: (1993)

Mapping discontinuous epitopes for MRK-16, UIC2 and 4E3 antibodies to extracellular loops 1 and 4 of human P-glycoprotein
por: Vahedi, Shahrooz, et al.
Publicado: (2018)

MrkH, a Novel c-di-GMP-Dependent Transcriptional Activator, Controls Klebsiella pneumoniae Biofilm Formation by Regulating Type 3 Fimbriae Expression
por: Wilksch, Jonathan J., et al.
Publicado: (2011)

Structural Insights into the Neutralization Properties of the Fully Human, Anti-interferon Monoclonal Antibody Sifalimumab
por: Oganesyan, Vaheh, et al.
Publicado: (2015)

Immune stealth-driven O2 serotype prevalence and potential for therapeutic antibodies against multidrug resistant Klebsiella pneumoniae
por: Pennini, Meghan E., et al.
Publicado: (2017)

New Flow Cytometric Method for Detection of Minimally Expressed Multidrug Resistance P‐Glycoprotein on Normal and Acute Leukemia Cells Using Biotinylated MRK16 and Streptavidin‐RED670 Conjugate
por: Takeshita, Akihiro, et al.
Publicado: (1995)

Regulation of antibody-mediated complement-dependent cytotoxicity by modulating the intrinsic affinity and binding valency of IgG for target antigen
por: Wang, Bo, et al.
Publicado: (2019)

Long-acting antibody ligand mimetics for HER4-selective agonism
por: Shan, Lu, et al.
Publicado: (2020)

Bi-Epitope SPR Surfaces: A Solution to Develop Robust Immunoassays
por: Peng, Li, et al.
Publicado: (2014)

Structural characterization of a human Fc fragment engineered for lack of effector functions
por: Oganesyan, Vaheh, et al.
Publicado: (2008)

Molecular basis for antagonistic activity of anifrolumab, an anti-interferon–α receptor 1 antibody
por: Peng, Li, et al.
Publicado: (2015)

Crystallization and preliminary X-ray diffraction analysis of the complex between a human anti-interferon antibody fragment and human interferon α-2A
por: Oganesyan, Vaheh, et al.
Publicado: (2008)

Molecular basis for the antagonistic activity of an anti-CXCR4 antibody
por: Peng, Li, et al.
Publicado: (2015)

A Novel Dual Expression Platform for High Throughput Functional Screening of Phage Libraries in Product like Format
por: Xiao, Xiaodong, et al.
Publicado: (2015)

Enhancement of Immune Effector Functions by Modulating IgG’s Intrinsic Affinity for Target Antigen
por: Mazor, Yariv, et al.
Publicado: (2016)

Insights into the molecular basis of a bispecific antibody's target selectivity
por: Mazor, Yariv, et al.
Publicado: (2015)

Molecular basis for the mechanism of action of an anti-TACE antibody
por: Peng, Li, et al.
Publicado: (2016)

Discovery and characterization of potent IL-21 neutralizing antibodies via a novel alternating antigen immunization and humanization strategy
por: Varkey, Reena, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_pe55jvqojk7jde11tl4o98u3b1