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Neuropathogenesis of Zika Virus in a Highly Susceptible Immunocompetent Mouse Model after Antibody Blockade of Type I Interferon

Animal models are needed to better understand the pathogenic mechanisms of Zika virus (ZIKV) and to evaluate candidate medical countermeasures. Adult mice infected with ZIKV develop a transient viremia, but do not demonstrate signs of morbidity or mortality. Mice deficient in type I or a combination...

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Detalles Bibliográficos
Autores principales:	Smith, Darci R., Hollidge, Bradley, Daye, Sharon, Zeng, Xiankun, Blancett, Candace, Kuszpit, Kyle, Bocan, Thomas, Koehler, Jeff W., Coyne, Susan, Minogue, Tim, Kenny, Tara, Chi, Xiaoli, Yim, Soojin, Miller, Lynn, Schmaljohn, Connie, Bavari, Sina, Golden, Joseph W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5249252/ https://www.ncbi.nlm.nih.gov/pubmed/28068342 http://dx.doi.org/10.1371/journal.pntd.0005296

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