Molecular landscape in acute myeloid leukemia: where do we stand in 2016

Acute myeloid leukemia (AML) is a clonal disorder characterized by the accumulation of complex genomic alterations that define the disease pathophysiology and overall outcome. Recent advances in sequencing technologies have described the molecular landscape of AML and identified several somatic alte...

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Detalles Bibliográficos
Autores principales: Al-Issa, Karam, Nazha, Aziz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Chinese Anti-Cancer Association 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5250605/
https://www.ncbi.nlm.nih.gov/pubmed/28154779
http://dx.doi.org/10.20892/j.issn.2095-3941.2016.0061
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author Al-Issa, Karam
Nazha, Aziz
author_facet Al-Issa, Karam
Nazha, Aziz
author_sort Al-Issa, Karam
collection PubMed
description Acute myeloid leukemia (AML) is a clonal disorder characterized by the accumulation of complex genomic alterations that define the disease pathophysiology and overall outcome. Recent advances in sequencing technologies have described the molecular landscape of AML and identified several somatic alterations that impact overall survival. Despite all these advancement, several challenges remain in translating this information into effective therapy. Herein we will review the molecular landscape of AML and discuss the impact of the most common somatic mutations on disease biology and outcome.
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spelling pubmed-52506052017-02-02 Molecular landscape in acute myeloid leukemia: where do we stand in 2016 Al-Issa, Karam Nazha, Aziz Cancer Biol Med Review Acute myeloid leukemia (AML) is a clonal disorder characterized by the accumulation of complex genomic alterations that define the disease pathophysiology and overall outcome. Recent advances in sequencing technologies have described the molecular landscape of AML and identified several somatic alterations that impact overall survival. Despite all these advancement, several challenges remain in translating this information into effective therapy. Herein we will review the molecular landscape of AML and discuss the impact of the most common somatic mutations on disease biology and outcome. Chinese Anti-Cancer Association 2016-12 /pmc/articles/PMC5250605/ /pubmed/28154779 http://dx.doi.org/10.20892/j.issn.2095-3941.2016.0061 Text en Copyright 2016 Cancer Biology & Medicine http://creativecommons.org/licenses/by-nc-sa/4.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-Share Alike 4.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/4.0/
spellingShingle Review
Al-Issa, Karam
Nazha, Aziz
Molecular landscape in acute myeloid leukemia: where do we stand in 2016
title Molecular landscape in acute myeloid leukemia: where do we stand in 2016
title_full Molecular landscape in acute myeloid leukemia: where do we stand in 2016
title_fullStr Molecular landscape in acute myeloid leukemia: where do we stand in 2016
title_full_unstemmed Molecular landscape in acute myeloid leukemia: where do we stand in 2016
title_short Molecular landscape in acute myeloid leukemia: where do we stand in 2016
title_sort molecular landscape in acute myeloid leukemia: where do we stand in 2016
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5250605/
https://www.ncbi.nlm.nih.gov/pubmed/28154779
http://dx.doi.org/10.20892/j.issn.2095-3941.2016.0061
work_keys_str_mv AT alissakaram molecularlandscapeinacutemyeloidleukemiawheredowestandin2016
AT nazhaaziz molecularlandscapeinacutemyeloidleukemiawheredowestandin2016

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