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Pharmacokinetics, Pharmacodynamics, and Safety of Entospletinib, a Novel pSYK Inhibitor, Following Single and Multiple Oral Dosing in Healthy Volunteers

BACKGROUND AND OBJECTIVES: Entospletinib is a selective, reversible, adenosine triphosphate-competitive small-molecule spleen tyrosine kinase (SYK) inhibitor that blocks B cell receptor-mediated signaling and proliferation in B lymphocytes. This study evaluated the safety, pharmacokinetics, and phar...

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Detalles Bibliográficos
Autores principales:	Ramanathan, Srini, Di Paolo, Julie A., Jin, Feng, Shao, Lixin, Sharma, Shringi, Robeson, Michelle, Kearney, Brian P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer International Publishing 2016
Materias:	Original Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5250654/ https://www.ncbi.nlm.nih.gov/pubmed/27785737 http://dx.doi.org/10.1007/s40261-016-0476-x

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