Downregulation of ARHGDIA contributes to human glioma progression through activation of Rho GTPase signaling pathway

The protein ARHGDIA has been found to play distinct roles in cancer progression for several tumors. However, it remains elusive whether and how ARHGDIA plays functions in human glioma. In this study, we discovered that ARHGDIA is much downregulated in human glioma; meanwhile, its expression negative...

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Autores principales: Lu, Weiliang, Wang, Xixi, Liu, Jingjing, He, Yu, Liang, Ziwei, Xia, Zijing, Cai, Ying, Zhou, Liangxue, Zhu, Hongxia, Liang, Shufang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5250662/
https://www.ncbi.nlm.nih.gov/pubmed/27726098
http://dx.doi.org/10.1007/s13277-016-5374-6
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author Lu, Weiliang
Wang, Xixi
Liu, Jingjing
He, Yu
Liang, Ziwei
Xia, Zijing
Cai, Ying
Zhou, Liangxue
Zhu, Hongxia
Liang, Shufang
author_facet Lu, Weiliang
Wang, Xixi
Liu, Jingjing
He, Yu
Liang, Ziwei
Xia, Zijing
Cai, Ying
Zhou, Liangxue
Zhu, Hongxia
Liang, Shufang
author_sort Lu, Weiliang
collection PubMed
description The protein ARHGDIA has been found to play distinct roles in cancer progression for several tumors. However, it remains elusive whether and how ARHGDIA plays functions in human glioma. In this study, we discovered that ARHGDIA is much downregulated in human glioma; meanwhile, its expression negatively correlates with glioma malignancy and positively relates to prognosis of glioma patients. It has independent predictive value of ARHGDIA expression level for overall survival of human glioma patients. Glioma patients with ARHGDIA-positive expression have a longer overall survival time than ARHGDIA-negative patients. Knockdown of ARHGDIA promotes cell proliferation, cell cycle progression, and cell migration due to the activation of Rho GTPases (Rac1, Cdc42, and RhoA) and Akt phosphorylation, whereas overexpression of ARHGDIA suppresses cell growth, cell cycle progression, and cell migration. ARHGDIA is a potential prognostic marker and therapeutic target for human glioma.
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spelling pubmed-52506622017-02-03 Downregulation of ARHGDIA contributes to human glioma progression through activation of Rho GTPase signaling pathway Lu, Weiliang Wang, Xixi Liu, Jingjing He, Yu Liang, Ziwei Xia, Zijing Cai, Ying Zhou, Liangxue Zhu, Hongxia Liang, Shufang Tumour Biol Original Article The protein ARHGDIA has been found to play distinct roles in cancer progression for several tumors. However, it remains elusive whether and how ARHGDIA plays functions in human glioma. In this study, we discovered that ARHGDIA is much downregulated in human glioma; meanwhile, its expression negatively correlates with glioma malignancy and positively relates to prognosis of glioma patients. It has independent predictive value of ARHGDIA expression level for overall survival of human glioma patients. Glioma patients with ARHGDIA-positive expression have a longer overall survival time than ARHGDIA-negative patients. Knockdown of ARHGDIA promotes cell proliferation, cell cycle progression, and cell migration due to the activation of Rho GTPases (Rac1, Cdc42, and RhoA) and Akt phosphorylation, whereas overexpression of ARHGDIA suppresses cell growth, cell cycle progression, and cell migration. ARHGDIA is a potential prognostic marker and therapeutic target for human glioma. Springer Netherlands 2016-10-10 /pmc/articles/PMC5250662/ /pubmed/27726098 http://dx.doi.org/10.1007/s13277-016-5374-6 Text en © The Author(s) 2016 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Original Article
Lu, Weiliang
Wang, Xixi
Liu, Jingjing
He, Yu
Liang, Ziwei
Xia, Zijing
Cai, Ying
Zhou, Liangxue
Zhu, Hongxia
Liang, Shufang
Downregulation of ARHGDIA contributes to human glioma progression through activation of Rho GTPase signaling pathway
title Downregulation of ARHGDIA contributes to human glioma progression through activation of Rho GTPase signaling pathway
title_full Downregulation of ARHGDIA contributes to human glioma progression through activation of Rho GTPase signaling pathway
title_fullStr Downregulation of ARHGDIA contributes to human glioma progression through activation of Rho GTPase signaling pathway
title_full_unstemmed Downregulation of ARHGDIA contributes to human glioma progression through activation of Rho GTPase signaling pathway
title_short Downregulation of ARHGDIA contributes to human glioma progression through activation of Rho GTPase signaling pathway
title_sort downregulation of arhgdia contributes to human glioma progression through activation of rho gtpase signaling pathway
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5250662/
https://www.ncbi.nlm.nih.gov/pubmed/27726098
http://dx.doi.org/10.1007/s13277-016-5374-6
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