DNA methyltransferases and their roles in tumorigenesis

DNA methylation plays an important role in gene expression, chromatin stability, and genetic imprinting. In mammals, DNA methylation patterns are written and regulated by DNA methyltransferases (DNMTs), including DNMT1, DNMT3A and DNMT3B. Recent emerging evidence shows that defects in DNMTs are invo...

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Detalles Bibliográficos
Autores principales: Zhang, Wu, Xu, Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5251331/
https://www.ncbi.nlm.nih.gov/pubmed/28127428
http://dx.doi.org/10.1186/s40364-017-0081-z
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author Zhang, Wu
Xu, Jie
author_facet Zhang, Wu
Xu, Jie
author_sort Zhang, Wu
collection PubMed
description DNA methylation plays an important role in gene expression, chromatin stability, and genetic imprinting. In mammals, DNA methylation patterns are written and regulated by DNA methyltransferases (DNMTs), including DNMT1, DNMT3A and DNMT3B. Recent emerging evidence shows that defects in DNMTs are involved in tumor transformation and progression, thus indicating that epigenetic disruptions caused by DNMT abnormalities are associated with tumorigenesis. Herein, we review the latest findings related to DNMT alterations in cancer cells and discuss the contributions of these effects to oncogenic phenotypes.
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spelling pubmed-52513312017-01-26 DNA methyltransferases and their roles in tumorigenesis Zhang, Wu Xu, Jie Biomark Res Review DNA methylation plays an important role in gene expression, chromatin stability, and genetic imprinting. In mammals, DNA methylation patterns are written and regulated by DNA methyltransferases (DNMTs), including DNMT1, DNMT3A and DNMT3B. Recent emerging evidence shows that defects in DNMTs are involved in tumor transformation and progression, thus indicating that epigenetic disruptions caused by DNMT abnormalities are associated with tumorigenesis. Herein, we review the latest findings related to DNMT alterations in cancer cells and discuss the contributions of these effects to oncogenic phenotypes. BioMed Central 2017-01-20 /pmc/articles/PMC5251331/ /pubmed/28127428 http://dx.doi.org/10.1186/s40364-017-0081-z Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Zhang, Wu
Xu, Jie
DNA methyltransferases and their roles in tumorigenesis
title DNA methyltransferases and their roles in tumorigenesis
title_full DNA methyltransferases and their roles in tumorigenesis
title_fullStr DNA methyltransferases and their roles in tumorigenesis
title_full_unstemmed DNA methyltransferases and their roles in tumorigenesis
title_short DNA methyltransferases and their roles in tumorigenesis
title_sort dna methyltransferases and their roles in tumorigenesis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5251331/
https://www.ncbi.nlm.nih.gov/pubmed/28127428
http://dx.doi.org/10.1186/s40364-017-0081-z
work_keys_str_mv AT zhangwu dnamethyltransferasesandtheirrolesintumorigenesis
AT xujie dnamethyltransferasesandtheirrolesintumorigenesis

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