Zebularine upregulates expression of CYP genes through inhibition of DNMT1 and PKR in HepG2 cells

Drug-induced hepatotoxicity is one of the major reasons cited for drug withdrawal. Therefore, it is of extreme importance to detect human hepatotoxic candidates as early as possible during the drug development process. In this study, we aimed to enhance hepatocyte functions such as CYP gene expressi...

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Detalles Bibliográficos
Autores principales: Nakamura, Kazuaki, Aizawa, Kazuko, Aung, Kyaw Htet, Yamauchi, Junji, Tanoue, Akito
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5253741/
https://www.ncbi.nlm.nih.gov/pubmed/28112215
http://dx.doi.org/10.1038/srep41093

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5253741/
https://www.ncbi.nlm.nih.gov/pubmed/28112215
http://dx.doi.org/10.1038/srep41093

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