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Zebularine upregulates expression of CYP genes through inhibition of DNMT1 and PKR in HepG2 cells
Drug-induced hepatotoxicity is one of the major reasons cited for drug withdrawal. Therefore, it is of extreme importance to detect human hepatotoxic candidates as early as possible during the drug development process. In this study, we aimed to enhance hepatocyte functions such as CYP gene expressi...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5253741/ https://www.ncbi.nlm.nih.gov/pubmed/28112215 http://dx.doi.org/10.1038/srep41093 |