Cargando…
Nanoscale Topography on Black Titanium Imparts Multi-biofunctional Properties for Orthopedic Applications
We have developed a chlorine based reactive ion etching process to yield randomly oriented anisotropic nanostructures that render the titanium metal surface ‘black’ similar to that of black silicon. The surface appears black due to the nanostructures in contrast to the conventional shiny surface of...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5253769/ https://www.ncbi.nlm.nih.gov/pubmed/28112235 http://dx.doi.org/10.1038/srep41118 |
_version_ | 1782498225047994368 |
---|---|
author | Hasan, Jafar Jain, Shubham Chatterjee, Kaushik |
author_facet | Hasan, Jafar Jain, Shubham Chatterjee, Kaushik |
author_sort | Hasan, Jafar |
collection | PubMed |
description | We have developed a chlorine based reactive ion etching process to yield randomly oriented anisotropic nanostructures that render the titanium metal surface ‘black’ similar to that of black silicon. The surface appears black due to the nanostructures in contrast to the conventional shiny surface of titanium. The nanostructures were found to kill bacteria on contact by mechanically rupturing the cells as has been observed previously on wings of certain insects. The etching was optimized to yield nanostructures of ≈1 μm height for maximal bactericidal efficiency without compromising cytocompatibility. Within 4 hours of contact with the black titanium surface, 95% ± 5% of E. coli, 98% ± 2% of P. aeruginosa, 92% ± 5% of M. smegmatis and 22% ± 8% of S. aureus cells that had attached were killed. The killing efficiency for the S. aureus increased to 76% ± 4% when the cells were allowed to adhere up to 24 hours. The black titanium supported the attachment and proliferation of human mesenchymal stem cells and augmented osteogenic lineage commitment in vitro. Thus, the bioinspired nanostructures on black titanium impart multi-biofunctional properties toward engineering the next-generation biomaterials for orthopedic implants. |
format | Online Article Text |
id | pubmed-5253769 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-52537692017-01-24 Nanoscale Topography on Black Titanium Imparts Multi-biofunctional Properties for Orthopedic Applications Hasan, Jafar Jain, Shubham Chatterjee, Kaushik Sci Rep Article We have developed a chlorine based reactive ion etching process to yield randomly oriented anisotropic nanostructures that render the titanium metal surface ‘black’ similar to that of black silicon. The surface appears black due to the nanostructures in contrast to the conventional shiny surface of titanium. The nanostructures were found to kill bacteria on contact by mechanically rupturing the cells as has been observed previously on wings of certain insects. The etching was optimized to yield nanostructures of ≈1 μm height for maximal bactericidal efficiency without compromising cytocompatibility. Within 4 hours of contact with the black titanium surface, 95% ± 5% of E. coli, 98% ± 2% of P. aeruginosa, 92% ± 5% of M. smegmatis and 22% ± 8% of S. aureus cells that had attached were killed. The killing efficiency for the S. aureus increased to 76% ± 4% when the cells were allowed to adhere up to 24 hours. The black titanium supported the attachment and proliferation of human mesenchymal stem cells and augmented osteogenic lineage commitment in vitro. Thus, the bioinspired nanostructures on black titanium impart multi-biofunctional properties toward engineering the next-generation biomaterials for orthopedic implants. Nature Publishing Group 2017-01-23 /pmc/articles/PMC5253769/ /pubmed/28112235 http://dx.doi.org/10.1038/srep41118 Text en Copyright © 2017, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Hasan, Jafar Jain, Shubham Chatterjee, Kaushik Nanoscale Topography on Black Titanium Imparts Multi-biofunctional Properties for Orthopedic Applications |
title | Nanoscale Topography on Black Titanium Imparts Multi-biofunctional Properties for Orthopedic Applications |
title_full | Nanoscale Topography on Black Titanium Imparts Multi-biofunctional Properties for Orthopedic Applications |
title_fullStr | Nanoscale Topography on Black Titanium Imparts Multi-biofunctional Properties for Orthopedic Applications |
title_full_unstemmed | Nanoscale Topography on Black Titanium Imparts Multi-biofunctional Properties for Orthopedic Applications |
title_short | Nanoscale Topography on Black Titanium Imparts Multi-biofunctional Properties for Orthopedic Applications |
title_sort | nanoscale topography on black titanium imparts multi-biofunctional properties for orthopedic applications |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5253769/ https://www.ncbi.nlm.nih.gov/pubmed/28112235 http://dx.doi.org/10.1038/srep41118 |
work_keys_str_mv | AT hasanjafar nanoscaletopographyonblacktitaniumimpartsmultibiofunctionalpropertiesfororthopedicapplications AT jainshubham nanoscaletopographyonblacktitaniumimpartsmultibiofunctionalpropertiesfororthopedicapplications AT chatterjeekaushik nanoscaletopographyonblacktitaniumimpartsmultibiofunctionalpropertiesfororthopedicapplications |