Genome Sequences of Diverse Human Cytomegalovirus Strains with Utility in Drug Screening and Vaccine Evaluation

Cytomegalovirus displays genetic heterogeneity, which has implications for antiviral and vaccine development. Many studies have focused on laboratory isolates that have been extensively adapted for growth on fibroblasts. Here, we report whole-genome sequences for 10 human cytomegalovirus (HCMV) stra...

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Detalles Bibliográficos
Autores principales: Corcoran, Kathleen, Sherrod, Carly J., Perkowski, Ellen F., Texier, Jordan, Li, Fengsheng, Wang, I-Ming, McVoy, Michael, Fu, Tong-Ming, Dittmer, Dirk P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2017
Materias:
Viruses
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5255926/
https://www.ncbi.nlm.nih.gov/pubmed/28104650
http://dx.doi.org/10.1128/genomeA.01433-16
Descripción
Sumario:Cytomegalovirus displays genetic heterogeneity, which has implications for antiviral and vaccine development. Many studies have focused on laboratory isolates that have been extensively adapted for growth on fibroblasts. Here, we report whole-genome sequences for 10 human cytomegalovirus (HCMV) strains that readily grow on ARPE-19 human retinal pigment epithelial cells.

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