Genome Sequences of Diverse Human Cytomegalovirus Strains with Utility in Drug Screening and Vaccine Evaluation

Cytomegalovirus displays genetic heterogeneity, which has implications for antiviral and vaccine development. Many studies have focused on laboratory isolates that have been extensively adapted for growth on fibroblasts. Here, we report whole-genome sequences for 10 human cytomegalovirus (HCMV) stra...

Descripción completa

Detalles Bibliográficos
Autores principales: Corcoran, Kathleen, Sherrod, Carly J., Perkowski, Ellen F., Texier, Jordan, Li, Fengsheng, Wang, I-Ming, McVoy, Michael, Fu, Tong-Ming, Dittmer, Dirk P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2017
Materias:
Viruses
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5255926/
https://www.ncbi.nlm.nih.gov/pubmed/28104650
http://dx.doi.org/10.1128/genomeA.01433-16
_version_ 1782498616314691584
author Corcoran, Kathleen
Sherrod, Carly J.
Perkowski, Ellen F.
Texier, Jordan
Li, Fengsheng
Wang, I-Ming
McVoy, Michael
Fu, Tong-Ming
Dittmer, Dirk P.
author_facet Corcoran, Kathleen
Sherrod, Carly J.
Perkowski, Ellen F.
Texier, Jordan
Li, Fengsheng
Wang, I-Ming
McVoy, Michael
Fu, Tong-Ming
Dittmer, Dirk P.
author_sort Corcoran, Kathleen
collection PubMed
description Cytomegalovirus displays genetic heterogeneity, which has implications for antiviral and vaccine development. Many studies have focused on laboratory isolates that have been extensively adapted for growth on fibroblasts. Here, we report whole-genome sequences for 10 human cytomegalovirus (HCMV) strains that readily grow on ARPE-19 human retinal pigment epithelial cells.
format Online
Article
Text
id pubmed-5255926
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher American Society for Microbiology
record_format MEDLINE/PubMed
spelling pubmed-52559262017-01-31 Genome Sequences of Diverse Human Cytomegalovirus Strains with Utility in Drug Screening and Vaccine Evaluation Corcoran, Kathleen Sherrod, Carly J. Perkowski, Ellen F. Texier, Jordan Li, Fengsheng Wang, I-Ming McVoy, Michael Fu, Tong-Ming Dittmer, Dirk P. Genome Announc Viruses Cytomegalovirus displays genetic heterogeneity, which has implications for antiviral and vaccine development. Many studies have focused on laboratory isolates that have been extensively adapted for growth on fibroblasts. Here, we report whole-genome sequences for 10 human cytomegalovirus (HCMV) strains that readily grow on ARPE-19 human retinal pigment epithelial cells. American Society for Microbiology 2017-01-19 /pmc/articles/PMC5255926/ /pubmed/28104650 http://dx.doi.org/10.1128/genomeA.01433-16 Text en Copyright © 2017 Corcoran et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license (http://creativecommons.org/licenses/by/4.0/) .
spellingShingle Viruses
Corcoran, Kathleen
Sherrod, Carly J.
Perkowski, Ellen F.
Texier, Jordan
Li, Fengsheng
Wang, I-Ming
McVoy, Michael
Fu, Tong-Ming
Dittmer, Dirk P.
Genome Sequences of Diverse Human Cytomegalovirus Strains with Utility in Drug Screening and Vaccine Evaluation
title Genome Sequences of Diverse Human Cytomegalovirus Strains with Utility in Drug Screening and Vaccine Evaluation
title_full Genome Sequences of Diverse Human Cytomegalovirus Strains with Utility in Drug Screening and Vaccine Evaluation
title_fullStr Genome Sequences of Diverse Human Cytomegalovirus Strains with Utility in Drug Screening and Vaccine Evaluation
title_full_unstemmed Genome Sequences of Diverse Human Cytomegalovirus Strains with Utility in Drug Screening and Vaccine Evaluation
title_short Genome Sequences of Diverse Human Cytomegalovirus Strains with Utility in Drug Screening and Vaccine Evaluation
title_sort genome sequences of diverse human cytomegalovirus strains with utility in drug screening and vaccine evaluation
topic Viruses
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5255926/
https://www.ncbi.nlm.nih.gov/pubmed/28104650
http://dx.doi.org/10.1128/genomeA.01433-16
work_keys_str_mv AT corcorankathleen genomesequencesofdiversehumancytomegalovirusstrainswithutilityindrugscreeningandvaccineevaluation
AT sherrodcarlyj genomesequencesofdiversehumancytomegalovirusstrainswithutilityindrugscreeningandvaccineevaluation
AT perkowskiellenf genomesequencesofdiversehumancytomegalovirusstrainswithutilityindrugscreeningandvaccineevaluation
AT texierjordan genomesequencesofdiversehumancytomegalovirusstrainswithutilityindrugscreeningandvaccineevaluation
AT lifengsheng genomesequencesofdiversehumancytomegalovirusstrainswithutilityindrugscreeningandvaccineevaluation
AT wangiming genomesequencesofdiversehumancytomegalovirusstrainswithutilityindrugscreeningandvaccineevaluation
AT mcvoymichael genomesequencesofdiversehumancytomegalovirusstrainswithutilityindrugscreeningandvaccineevaluation
AT futongming genomesequencesofdiversehumancytomegalovirusstrainswithutilityindrugscreeningandvaccineevaluation
AT dittmerdirkp genomesequencesofdiversehumancytomegalovirusstrainswithutilityindrugscreeningandvaccineevaluation

Ejemplares similares