Thrombotic microangiopathy: An unusual cause of renal failure in rheumatoid arthritis

Rheumatoid arthritis (RA) is one of the commonest rheumatological diseases. Renal involvement is not common but can occur as a result of chronic inflammation as part of disease process or drug toxicity. Thrombotic microangiopathy (TMA) is characterized by microangiopathic hemolytic anemia, thrombocy...

Descripción completa

Detalles Bibliográficos
Autores principales: Sakthirajan, R., Dhanapriya, J., Dineshkumar, T., Gopalakrishnan, N., Murugan, S., Balasubramaniyan, T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2017
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5255999/
https://www.ncbi.nlm.nih.gov/pubmed/28182045
http://dx.doi.org/10.4103/0971-4065.179207
_version_ 1782498628145774592
author Sakthirajan, R.
Dhanapriya, J.
Dineshkumar, T.
Gopalakrishnan, N.
Murugan, S.
Balasubramaniyan, T.
author_facet Sakthirajan, R.
Dhanapriya, J.
Dineshkumar, T.
Gopalakrishnan, N.
Murugan, S.
Balasubramaniyan, T.
author_sort Sakthirajan, R.
collection PubMed
description Rheumatoid arthritis (RA) is one of the commonest rheumatological diseases. Renal involvement is not common but can occur as a result of chronic inflammation as part of disease process or drug toxicity. Thrombotic microangiopathy (TMA) is characterized by microangiopathic hemolytic anemia, thrombocytopenia, and organ failure of variable severity. Only a few cases of TMA in patients with RA were reported to date. We describe a 45-year-old female patient with RA who presented with oliguria and edema. Renal biopsy showed TMA with patchy cortical necrosis. She improved with hemodialysis and plasmapheresis.
format Online
Article
Text
id pubmed-5255999
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Medknow Publications & Media Pvt Ltd
record_format MEDLINE/PubMed
spelling pubmed-52559992017-02-08 Thrombotic microangiopathy: An unusual cause of renal failure in rheumatoid arthritis Sakthirajan, R. Dhanapriya, J. Dineshkumar, T. Gopalakrishnan, N. Murugan, S. Balasubramaniyan, T. Indian J Nephrol Case Report Rheumatoid arthritis (RA) is one of the commonest rheumatological diseases. Renal involvement is not common but can occur as a result of chronic inflammation as part of disease process or drug toxicity. Thrombotic microangiopathy (TMA) is characterized by microangiopathic hemolytic anemia, thrombocytopenia, and organ failure of variable severity. Only a few cases of TMA in patients with RA were reported to date. We describe a 45-year-old female patient with RA who presented with oliguria and edema. Renal biopsy showed TMA with patchy cortical necrosis. She improved with hemodialysis and plasmapheresis. Medknow Publications & Media Pvt Ltd 2017 /pmc/articles/PMC5255999/ /pubmed/28182045 http://dx.doi.org/10.4103/0971-4065.179207 Text en Copyright: © 2017 Indian Journal of Nephrology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Case Report
Sakthirajan, R.
Dhanapriya, J.
Dineshkumar, T.
Gopalakrishnan, N.
Murugan, S.
Balasubramaniyan, T.
Thrombotic microangiopathy: An unusual cause of renal failure in rheumatoid arthritis
title Thrombotic microangiopathy: An unusual cause of renal failure in rheumatoid arthritis
title_full Thrombotic microangiopathy: An unusual cause of renal failure in rheumatoid arthritis
title_fullStr Thrombotic microangiopathy: An unusual cause of renal failure in rheumatoid arthritis
title_full_unstemmed Thrombotic microangiopathy: An unusual cause of renal failure in rheumatoid arthritis
title_short Thrombotic microangiopathy: An unusual cause of renal failure in rheumatoid arthritis
title_sort thrombotic microangiopathy: an unusual cause of renal failure in rheumatoid arthritis
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5255999/
https://www.ncbi.nlm.nih.gov/pubmed/28182045
http://dx.doi.org/10.4103/0971-4065.179207
work_keys_str_mv AT sakthirajanr thromboticmicroangiopathyanunusualcauseofrenalfailureinrheumatoidarthritis
AT dhanapriyaj thromboticmicroangiopathyanunusualcauseofrenalfailureinrheumatoidarthritis
AT dineshkumart thromboticmicroangiopathyanunusualcauseofrenalfailureinrheumatoidarthritis
AT gopalakrishnann thromboticmicroangiopathyanunusualcauseofrenalfailureinrheumatoidarthritis
AT murugans thromboticmicroangiopathyanunusualcauseofrenalfailureinrheumatoidarthritis
AT balasubramaniyant thromboticmicroangiopathyanunusualcauseofrenalfailureinrheumatoidarthritis

Ejemplares similares