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Improvement of hemodynamic performance using novel helical flow vena cava filter design

We propose a vena cava filter in which helical flow is created in the filter’s working zone to minimize filter blockage by trapped clots and facilitate the lysis of trapped clots. To validate this new design, we compared five helical flow inducers with different thread pitches in terms of blood flow...

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Detalles Bibliográficos
Autores principales: Chen, Ying, Zhang, Peng, Deng, Xiaoyan, Fan, Yubo, Xing, Yubin, Xing, Ning
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5256025/
https://www.ncbi.nlm.nih.gov/pubmed/28112186
http://dx.doi.org/10.1038/srep40724
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author Chen, Ying
Zhang, Peng
Deng, Xiaoyan
Fan, Yubo
Xing, Yubin
Xing, Ning
author_facet Chen, Ying
Zhang, Peng
Deng, Xiaoyan
Fan, Yubo
Xing, Yubin
Xing, Ning
author_sort Chen, Ying
collection PubMed
description We propose a vena cava filter in which helical flow is created in the filter’s working zone to minimize filter blockage by trapped clots and facilitate the lysis of trapped clots. To validate this new design, we compared five helical flow inducers with different thread pitches in terms of blood flow patterns in the filter. The vena cava was reconstructed based on computed tomography images. Both the numerical simulation and in vitro experiment revealed that the helical flow inducer can effectively create a helical flow in the vessel, thereby subduing the filter structure’s adverse disruption to blood flow, and increasing flow-induced shear stress in the filter center. In addition, the smaller thread pitch helical flow inducer reduced the oscillating shear index and relative residence time on the vessel wall. Moreover, we observed that the helical flow inducer in the vena cava could induce flow rotation both in clockwise and counterclockwise directions. In conclusion, the new design of the filter with the smaller thread pitch inducer is advantageous over the traditional filter in terms of improving local hemodynamics, which may reduce thrombosis build-up after deployment.
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spelling pubmed-52560252017-01-24 Improvement of hemodynamic performance using novel helical flow vena cava filter design Chen, Ying Zhang, Peng Deng, Xiaoyan Fan, Yubo Xing, Yubin Xing, Ning Sci Rep Article We propose a vena cava filter in which helical flow is created in the filter’s working zone to minimize filter blockage by trapped clots and facilitate the lysis of trapped clots. To validate this new design, we compared five helical flow inducers with different thread pitches in terms of blood flow patterns in the filter. The vena cava was reconstructed based on computed tomography images. Both the numerical simulation and in vitro experiment revealed that the helical flow inducer can effectively create a helical flow in the vessel, thereby subduing the filter structure’s adverse disruption to blood flow, and increasing flow-induced shear stress in the filter center. In addition, the smaller thread pitch helical flow inducer reduced the oscillating shear index and relative residence time on the vessel wall. Moreover, we observed that the helical flow inducer in the vena cava could induce flow rotation both in clockwise and counterclockwise directions. In conclusion, the new design of the filter with the smaller thread pitch inducer is advantageous over the traditional filter in terms of improving local hemodynamics, which may reduce thrombosis build-up after deployment. Nature Publishing Group 2017-01-23 /pmc/articles/PMC5256025/ /pubmed/28112186 http://dx.doi.org/10.1038/srep40724 Text en Copyright © 2017, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Chen, Ying
Zhang, Peng
Deng, Xiaoyan
Fan, Yubo
Xing, Yubin
Xing, Ning
Improvement of hemodynamic performance using novel helical flow vena cava filter design
title Improvement of hemodynamic performance using novel helical flow vena cava filter design
title_full Improvement of hemodynamic performance using novel helical flow vena cava filter design
title_fullStr Improvement of hemodynamic performance using novel helical flow vena cava filter design
title_full_unstemmed Improvement of hemodynamic performance using novel helical flow vena cava filter design
title_short Improvement of hemodynamic performance using novel helical flow vena cava filter design
title_sort improvement of hemodynamic performance using novel helical flow vena cava filter design
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5256025/
https://www.ncbi.nlm.nih.gov/pubmed/28112186
http://dx.doi.org/10.1038/srep40724
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