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Endothelia-Targeting Protection by Escin in Decompression Sickness Rats
Endothelial dysfunction is involved in the pathogenesis of decompression sickness (DCS) and contributes substantively to subsequent inflammatory responses. Escin, the main active compound in horse chestnut seed extract, is well known for its endothelial protection and anti-inflammatory properties. T...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5256092/ https://www.ncbi.nlm.nih.gov/pubmed/28112272 http://dx.doi.org/10.1038/srep41288 |
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author | Zhang, Kun Jiang, Zhongxin Ning, Xiaowei Yu, Xuhua Xu, Jiajun Buzzacott, Peter Xu, Weigang |
author_facet | Zhang, Kun Jiang, Zhongxin Ning, Xiaowei Yu, Xuhua Xu, Jiajun Buzzacott, Peter Xu, Weigang |
author_sort | Zhang, Kun |
collection | PubMed |
description | Endothelial dysfunction is involved in the pathogenesis of decompression sickness (DCS) and contributes substantively to subsequent inflammatory responses. Escin, the main active compound in horse chestnut seed extract, is well known for its endothelial protection and anti-inflammatory properties. This study aimed to investigate the potential protection of escin against DCS in rats. Escin was administered orally to adult male rats for 7 d (1.8 mg/kg/day) before a simulated air dive. After decompression, signs of DCS were monitored, and blood and pulmonary tissue were sampled for the detection of endothelia related indices. The incidence and mortality of DCS were postponed and decreased significantly in rats treated with escin compared with those treated with saline (P < 0.05). Escin significantly ameliorated endothelial dysfunction (increased serum E-selectin and ICAM-1 and lung Wet/Dry ratio, decreased serum NO), and oxidative and inflammatory responses (increased serum MDA, MPO, IL-6 and TNF-α) (P < 0.05 or P < 0.01). The results suggest escin has beneficial effects on DCS related to its endothelia-protective properties and might be a drug candidate for DCS prevention and treatment. |
format | Online Article Text |
id | pubmed-5256092 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-52560922017-01-24 Endothelia-Targeting Protection by Escin in Decompression Sickness Rats Zhang, Kun Jiang, Zhongxin Ning, Xiaowei Yu, Xuhua Xu, Jiajun Buzzacott, Peter Xu, Weigang Sci Rep Article Endothelial dysfunction is involved in the pathogenesis of decompression sickness (DCS) and contributes substantively to subsequent inflammatory responses. Escin, the main active compound in horse chestnut seed extract, is well known for its endothelial protection and anti-inflammatory properties. This study aimed to investigate the potential protection of escin against DCS in rats. Escin was administered orally to adult male rats for 7 d (1.8 mg/kg/day) before a simulated air dive. After decompression, signs of DCS were monitored, and blood and pulmonary tissue were sampled for the detection of endothelia related indices. The incidence and mortality of DCS were postponed and decreased significantly in rats treated with escin compared with those treated with saline (P < 0.05). Escin significantly ameliorated endothelial dysfunction (increased serum E-selectin and ICAM-1 and lung Wet/Dry ratio, decreased serum NO), and oxidative and inflammatory responses (increased serum MDA, MPO, IL-6 and TNF-α) (P < 0.05 or P < 0.01). The results suggest escin has beneficial effects on DCS related to its endothelia-protective properties and might be a drug candidate for DCS prevention and treatment. Nature Publishing Group 2017-01-23 /pmc/articles/PMC5256092/ /pubmed/28112272 http://dx.doi.org/10.1038/srep41288 Text en Copyright © 2017, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Zhang, Kun Jiang, Zhongxin Ning, Xiaowei Yu, Xuhua Xu, Jiajun Buzzacott, Peter Xu, Weigang Endothelia-Targeting Protection by Escin in Decompression Sickness Rats |
title | Endothelia-Targeting Protection by Escin in Decompression Sickness Rats |
title_full | Endothelia-Targeting Protection by Escin in Decompression Sickness Rats |
title_fullStr | Endothelia-Targeting Protection by Escin in Decompression Sickness Rats |
title_full_unstemmed | Endothelia-Targeting Protection by Escin in Decompression Sickness Rats |
title_short | Endothelia-Targeting Protection by Escin in Decompression Sickness Rats |
title_sort | endothelia-targeting protection by escin in decompression sickness rats |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5256092/ https://www.ncbi.nlm.nih.gov/pubmed/28112272 http://dx.doi.org/10.1038/srep41288 |
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