Developmental Expression of 4-Repeat-Tau Induces Neuronal Aneuploidy in Drosophila Tauopathy Models

Tau-mediated neurodegeneration in Alzheimer’s disease and tauopathies is generally assumed to start in a normally developed brain. However, several lines of evidence suggest that impaired Tau isoform expression during development could affect mitosis and ploidy in post-mitotic differentiated tissue....

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Detalles Bibliográficos
Autores principales: Malmanche, Nicolas, Dourlen, Pierre, Gistelinck, Marc, Demiautte, Florie, Link, Nichole, Dupont, Cloé, Vanden Broeck, Lies, Werkmeister, Elisabeth, Amouyel, Philippe, Bongiovanni, Antonino, Bauderlique, Hélène, Moechars, Dieder, Royou, Anne, Bellen, Hugo J., Lafont, Frank, Callaerts, Patrick, Lambert, Jean-Charles, Dermaut, Bart
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5256094/
https://www.ncbi.nlm.nih.gov/pubmed/28112163
http://dx.doi.org/10.1038/srep40764

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