Loss of Merlin induces metabolomic adaptation that engages dependence on Hedgehog signaling

The tumor suppressor protein Merlin is proteasomally degraded in breast cancer. We undertook an untargeted metabolomics approach to discern the global metabolomics profile impacted by Merlin in breast cancer cells. We discerned specific changes in glutathione metabolites that uncovered novel facets...

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Detalles Bibliográficos
Autores principales: Das, Shamik, Jackson, William P., Prasain, Jeevan K., Hanna, Ann, Bailey, Sarah K., Tucker, J. Allan, Bae, Sejong, Wilson, Landon S., Samant, Rajeev S., Barnes, Stephen, Shevde, Lalita A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5256100/
https://www.ncbi.nlm.nih.gov/pubmed/28112165
http://dx.doi.org/10.1038/srep40773

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5256100/
https://www.ncbi.nlm.nih.gov/pubmed/28112165
http://dx.doi.org/10.1038/srep40773

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