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Effect of acupuncture ‘dose’ on modulation of the default mode network of the brain
OBJECTIVE: Recent functional MRI (fMRI) studies show that brain activity, including the default mode network (DMN), can be modulated by acupuncture. Conventional means to enhance the neurophysiological ‘dose’ of acupuncture, including an increased number of needles and manual needle manipulation, ar...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMJ Publishing Group
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5256125/ https://www.ncbi.nlm.nih.gov/pubmed/27841974 http://dx.doi.org/10.1136/acupmed-2016-011071 |
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author | Lin, Yii-Jeng Kung, Yen-Ying Kuo, Wen-Jui Niddam, David M Chou, Chih-Che Cheng, Chou-Ming Yeh, Tzu-Chen Hsieh, Jen-Chuen Chiu, Jen-Hwey |
author_facet | Lin, Yii-Jeng Kung, Yen-Ying Kuo, Wen-Jui Niddam, David M Chou, Chih-Che Cheng, Chou-Ming Yeh, Tzu-Chen Hsieh, Jen-Chuen Chiu, Jen-Hwey |
author_sort | Lin, Yii-Jeng |
collection | PubMed |
description | OBJECTIVE: Recent functional MRI (fMRI) studies show that brain activity, including the default mode network (DMN), can be modulated by acupuncture. Conventional means to enhance the neurophysiological ‘dose’ of acupuncture, including an increased number of needles and manual needle manipulation, are expected to enhance its physiological effects. The aim of this study was to compare the effects of both methods on brain activity. METHODS: 58 healthy volunteers were randomly assigned into four groups that received single needle acupuncture (SNA, n=15) or transcutaneous electrical nerve stimulation (TENS, n=13) as active controls, or enhanced acupuncture by way of three needle acupuncture (TNA, n=17) or SNA plus manual stimulation (SNA+MS, n=13). Treatment-associated sensations were evaluated using a visual analogue scale. Central responses were recorded before, during, and after treatment at LI4 on the left hand using resting state fMRI. RESULTS: TNA and SNA+MS induced DMN-insula activity and extensive DMN activity compared to SNA, despite comparable levels of de qi sensation. The TNA and SNA+MS groups exhibited a delayed and enhanced modulation of the DMN, which was not observed followed SNA and TENS. Furthermore, TNA increased precuneus activity and increased the DMN-related activity of the cuneus and left insula, while SNA+MS increased activity in the right insula. CONCLUSIONS: The results showed that conventional methods to enhance the acupuncture dose induce different DMN modulatory effects. TNA induces the most extensive DMN modulation, compared with other methods. Conventional methods of enhancing the acupuncture dose could potentially be applied as a means of modulating brain activity. |
format | Online Article Text |
id | pubmed-5256125 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | BMJ Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-52561252017-01-25 Effect of acupuncture ‘dose’ on modulation of the default mode network of the brain Lin, Yii-Jeng Kung, Yen-Ying Kuo, Wen-Jui Niddam, David M Chou, Chih-Che Cheng, Chou-Ming Yeh, Tzu-Chen Hsieh, Jen-Chuen Chiu, Jen-Hwey Acupunct Med Original Paper OBJECTIVE: Recent functional MRI (fMRI) studies show that brain activity, including the default mode network (DMN), can be modulated by acupuncture. Conventional means to enhance the neurophysiological ‘dose’ of acupuncture, including an increased number of needles and manual needle manipulation, are expected to enhance its physiological effects. The aim of this study was to compare the effects of both methods on brain activity. METHODS: 58 healthy volunteers were randomly assigned into four groups that received single needle acupuncture (SNA, n=15) or transcutaneous electrical nerve stimulation (TENS, n=13) as active controls, or enhanced acupuncture by way of three needle acupuncture (TNA, n=17) or SNA plus manual stimulation (SNA+MS, n=13). Treatment-associated sensations were evaluated using a visual analogue scale. Central responses were recorded before, during, and after treatment at LI4 on the left hand using resting state fMRI. RESULTS: TNA and SNA+MS induced DMN-insula activity and extensive DMN activity compared to SNA, despite comparable levels of de qi sensation. The TNA and SNA+MS groups exhibited a delayed and enhanced modulation of the DMN, which was not observed followed SNA and TENS. Furthermore, TNA increased precuneus activity and increased the DMN-related activity of the cuneus and left insula, while SNA+MS increased activity in the right insula. CONCLUSIONS: The results showed that conventional methods to enhance the acupuncture dose induce different DMN modulatory effects. TNA induces the most extensive DMN modulation, compared with other methods. Conventional methods of enhancing the acupuncture dose could potentially be applied as a means of modulating brain activity. BMJ Publishing Group 2016-12 2016-10-06 /pmc/articles/PMC5256125/ /pubmed/27841974 http://dx.doi.org/10.1136/acupmed-2016-011071 Text en Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/ This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
spellingShingle | Original Paper Lin, Yii-Jeng Kung, Yen-Ying Kuo, Wen-Jui Niddam, David M Chou, Chih-Che Cheng, Chou-Ming Yeh, Tzu-Chen Hsieh, Jen-Chuen Chiu, Jen-Hwey Effect of acupuncture ‘dose’ on modulation of the default mode network of the brain |
title | Effect of acupuncture ‘dose’ on modulation of the default mode network of the brain |
title_full | Effect of acupuncture ‘dose’ on modulation of the default mode network of the brain |
title_fullStr | Effect of acupuncture ‘dose’ on modulation of the default mode network of the brain |
title_full_unstemmed | Effect of acupuncture ‘dose’ on modulation of the default mode network of the brain |
title_short | Effect of acupuncture ‘dose’ on modulation of the default mode network of the brain |
title_sort | effect of acupuncture ‘dose’ on modulation of the default mode network of the brain |
topic | Original Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5256125/ https://www.ncbi.nlm.nih.gov/pubmed/27841974 http://dx.doi.org/10.1136/acupmed-2016-011071 |
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