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Electrophysiologic effects of the I(K) (1) inhibitor PA‐6 are modulated by extracellular potassium in isolated guinea pig hearts

The pentamidine analog PA‐6 was developed as a specific inward rectifier potassium current (I(K) (1)) antagonist, because established inhibitors either lack specificity or have side effects that prohibit their use in vivo. We previously demonstrated that BaCl(2), an established I(K) (1) inhibitor, c...

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Detalles Bibliográficos
Autores principales: Hoeker, Gregory S., Skarsfeldt, Mark A., Jespersen, Thomas, Poelzing, Steven
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5256165/
https://www.ncbi.nlm.nih.gov/pubmed/28087819
http://dx.doi.org/10.14814/phy2.13120