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An altered endometrial CD8 tissue resident memory T cell population in recurrent miscarriage
When trying to conceive 1% of couples have recurrent miscarriages, defined as three or more consecutive pregnancy losses. This is not accounted for by the known incidence of chromosomal aneuploidy in miscarriage, and it has been suggested that there is an immunological aetiology. The endometrial muc...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5256279/ https://www.ncbi.nlm.nih.gov/pubmed/28112260 http://dx.doi.org/10.1038/srep41335 |
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author | Southcombe, J. H. Mounce, G. McGee, K. Elghajiji, A. Brosens, J. Quenby, S. Child, T. Granne, I. |
author_facet | Southcombe, J. H. Mounce, G. McGee, K. Elghajiji, A. Brosens, J. Quenby, S. Child, T. Granne, I. |
author_sort | Southcombe, J. H. |
collection | PubMed |
description | When trying to conceive 1% of couples have recurrent miscarriages, defined as three or more consecutive pregnancy losses. This is not accounted for by the known incidence of chromosomal aneuploidy in miscarriage, and it has been suggested that there is an immunological aetiology. The endometrial mucosa is populated by a variety of immune cells which in addition to providing host pathogen immunity must facilitate pregnancy. Here we characterise the endometrial CD8-T cell population during the embryonic window of implantation and find that the majority of cells are tissue resident memory T cells with high levels of CD69 and CD103 expression, proteins that prevent cells egress. We demonstrate that unexplained recurrent miscarriage is associated with significantly decreased expression of the T-cell co-receptor CD8 and tissue residency marker CD69. These cells differ from those found in control women, with less expression of CD127 indicating a lack of homeostatic cell control through IL-7 signalling. Nevertheless this population is resident in the endometrium of women who have RM, more than three months after the last miscarriage, indicating that the memory CD8-T cell population is altered in RM patients. This is the first evidence of a differing pre-pregnancy phenotype in endometrial immune cells in RM. |
format | Online Article Text |
id | pubmed-5256279 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-52562792017-01-24 An altered endometrial CD8 tissue resident memory T cell population in recurrent miscarriage Southcombe, J. H. Mounce, G. McGee, K. Elghajiji, A. Brosens, J. Quenby, S. Child, T. Granne, I. Sci Rep Article When trying to conceive 1% of couples have recurrent miscarriages, defined as three or more consecutive pregnancy losses. This is not accounted for by the known incidence of chromosomal aneuploidy in miscarriage, and it has been suggested that there is an immunological aetiology. The endometrial mucosa is populated by a variety of immune cells which in addition to providing host pathogen immunity must facilitate pregnancy. Here we characterise the endometrial CD8-T cell population during the embryonic window of implantation and find that the majority of cells are tissue resident memory T cells with high levels of CD69 and CD103 expression, proteins that prevent cells egress. We demonstrate that unexplained recurrent miscarriage is associated with significantly decreased expression of the T-cell co-receptor CD8 and tissue residency marker CD69. These cells differ from those found in control women, with less expression of CD127 indicating a lack of homeostatic cell control through IL-7 signalling. Nevertheless this population is resident in the endometrium of women who have RM, more than three months after the last miscarriage, indicating that the memory CD8-T cell population is altered in RM patients. This is the first evidence of a differing pre-pregnancy phenotype in endometrial immune cells in RM. Nature Publishing Group 2017-01-23 /pmc/articles/PMC5256279/ /pubmed/28112260 http://dx.doi.org/10.1038/srep41335 Text en Copyright © 2017, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Southcombe, J. H. Mounce, G. McGee, K. Elghajiji, A. Brosens, J. Quenby, S. Child, T. Granne, I. An altered endometrial CD8 tissue resident memory T cell population in recurrent miscarriage |
title | An altered endometrial CD8 tissue resident memory T cell population in recurrent miscarriage |
title_full | An altered endometrial CD8 tissue resident memory T cell population in recurrent miscarriage |
title_fullStr | An altered endometrial CD8 tissue resident memory T cell population in recurrent miscarriage |
title_full_unstemmed | An altered endometrial CD8 tissue resident memory T cell population in recurrent miscarriage |
title_short | An altered endometrial CD8 tissue resident memory T cell population in recurrent miscarriage |
title_sort | altered endometrial cd8 tissue resident memory t cell population in recurrent miscarriage |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5256279/ https://www.ncbi.nlm.nih.gov/pubmed/28112260 http://dx.doi.org/10.1038/srep41335 |
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