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Duration of Pulmonary Tuberculosis Infectiousness under Adequate Therapy, as Assessed Using Induced Sputum Samples

BACKGROUND: A sputum culture is the most reliable indicator of the infectiousness of pulmonary tuberculosis (PTB); however, a spontaneous sputum specimen may not be suitable. The aim of this study was to evaluate the infectious period in patients with non–drug-resistant (DR) PTB receiving adequate s...

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Autores principales: Ko, Yousang, Shin, Jeong Hwan, Lee, Hyun-Kyung, Lee, Young Seok, Lee, Suh-Young, Park, So Young, Mo, Eun-Kyung, Kim, Changhwan, Park, Yong Bum
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Academy of Tuberculosis and Respiratory Diseases 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5256343/
https://www.ncbi.nlm.nih.gov/pubmed/28119744
http://dx.doi.org/10.4046/trd.2017.80.1.27
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author Ko, Yousang
Shin, Jeong Hwan
Lee, Hyun-Kyung
Lee, Young Seok
Lee, Suh-Young
Park, So Young
Mo, Eun-Kyung
Kim, Changhwan
Park, Yong Bum
author_facet Ko, Yousang
Shin, Jeong Hwan
Lee, Hyun-Kyung
Lee, Young Seok
Lee, Suh-Young
Park, So Young
Mo, Eun-Kyung
Kim, Changhwan
Park, Yong Bum
author_sort Ko, Yousang
collection PubMed
description BACKGROUND: A sputum culture is the most reliable indicator of the infectiousness of pulmonary tuberculosis (PTB); however, a spontaneous sputum specimen may not be suitable. The aim of this study was to evaluate the infectious period in patients with non–drug-resistant (DR) PTB receiving adequate standard chemotherapy, using induced sputum (IS) specimens. METHODS: We evaluated the duration of infectiousness of PTB using a retrospective cohort design. RESULTS: Among the 35 patients with PTB, 22 were smear-positive. The rates of IS culture positivity from baseline to the sixth week of anti-tuberculosis medication in the smear-positive PTB group were 100%, 100%, 91%, 73%, 36%, and 18%, respectively. For smear-positive PTB cases, the median time of conversion to culture negativity was 35.0 days (range, 28.0–42.0 days). In the smear-negative PTB group (n=13), the weekly rates of positive IS culture were 100%, 77%, 39%, 8%, 0%, and 0%, respectively, and the median time to conversion to culture-negative was 21.0 days (range, 17.5–28.0 days). CONCLUSION: The infectiousness of PTB, under adequate therapy, may persist longer than previously reported, even in patients with non-DR PTB.
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spelling pubmed-52563432017-01-24 Duration of Pulmonary Tuberculosis Infectiousness under Adequate Therapy, as Assessed Using Induced Sputum Samples Ko, Yousang Shin, Jeong Hwan Lee, Hyun-Kyung Lee, Young Seok Lee, Suh-Young Park, So Young Mo, Eun-Kyung Kim, Changhwan Park, Yong Bum Tuberc Respir Dis (Seoul) Original Article BACKGROUND: A sputum culture is the most reliable indicator of the infectiousness of pulmonary tuberculosis (PTB); however, a spontaneous sputum specimen may not be suitable. The aim of this study was to evaluate the infectious period in patients with non–drug-resistant (DR) PTB receiving adequate standard chemotherapy, using induced sputum (IS) specimens. METHODS: We evaluated the duration of infectiousness of PTB using a retrospective cohort design. RESULTS: Among the 35 patients with PTB, 22 were smear-positive. The rates of IS culture positivity from baseline to the sixth week of anti-tuberculosis medication in the smear-positive PTB group were 100%, 100%, 91%, 73%, 36%, and 18%, respectively. For smear-positive PTB cases, the median time of conversion to culture negativity was 35.0 days (range, 28.0–42.0 days). In the smear-negative PTB group (n=13), the weekly rates of positive IS culture were 100%, 77%, 39%, 8%, 0%, and 0%, respectively, and the median time to conversion to culture-negative was 21.0 days (range, 17.5–28.0 days). CONCLUSION: The infectiousness of PTB, under adequate therapy, may persist longer than previously reported, even in patients with non-DR PTB. The Korean Academy of Tuberculosis and Respiratory Diseases 2017-01 2016-12-30 /pmc/articles/PMC5256343/ /pubmed/28119744 http://dx.doi.org/10.4046/trd.2017.80.1.27 Text en Copyright©2017. The Korean Academy of Tuberculosis and Respiratory Diseases. All rights reserved. http://creativecommons.org/licenses/by-nc/4.0/ It is identical to the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/)
spellingShingle Original Article
Ko, Yousang
Shin, Jeong Hwan
Lee, Hyun-Kyung
Lee, Young Seok
Lee, Suh-Young
Park, So Young
Mo, Eun-Kyung
Kim, Changhwan
Park, Yong Bum
Duration of Pulmonary Tuberculosis Infectiousness under Adequate Therapy, as Assessed Using Induced Sputum Samples
title Duration of Pulmonary Tuberculosis Infectiousness under Adequate Therapy, as Assessed Using Induced Sputum Samples
title_full Duration of Pulmonary Tuberculosis Infectiousness under Adequate Therapy, as Assessed Using Induced Sputum Samples
title_fullStr Duration of Pulmonary Tuberculosis Infectiousness under Adequate Therapy, as Assessed Using Induced Sputum Samples
title_full_unstemmed Duration of Pulmonary Tuberculosis Infectiousness under Adequate Therapy, as Assessed Using Induced Sputum Samples
title_short Duration of Pulmonary Tuberculosis Infectiousness under Adequate Therapy, as Assessed Using Induced Sputum Samples
title_sort duration of pulmonary tuberculosis infectiousness under adequate therapy, as assessed using induced sputum samples
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5256343/
https://www.ncbi.nlm.nih.gov/pubmed/28119744
http://dx.doi.org/10.4046/trd.2017.80.1.27
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