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Duration of Pulmonary Tuberculosis Infectiousness under Adequate Therapy, as Assessed Using Induced Sputum Samples
BACKGROUND: A sputum culture is the most reliable indicator of the infectiousness of pulmonary tuberculosis (PTB); however, a spontaneous sputum specimen may not be suitable. The aim of this study was to evaluate the infectious period in patients with non–drug-resistant (DR) PTB receiving adequate s...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Korean Academy of Tuberculosis and Respiratory Diseases
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5256343/ https://www.ncbi.nlm.nih.gov/pubmed/28119744 http://dx.doi.org/10.4046/trd.2017.80.1.27 |
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author | Ko, Yousang Shin, Jeong Hwan Lee, Hyun-Kyung Lee, Young Seok Lee, Suh-Young Park, So Young Mo, Eun-Kyung Kim, Changhwan Park, Yong Bum |
author_facet | Ko, Yousang Shin, Jeong Hwan Lee, Hyun-Kyung Lee, Young Seok Lee, Suh-Young Park, So Young Mo, Eun-Kyung Kim, Changhwan Park, Yong Bum |
author_sort | Ko, Yousang |
collection | PubMed |
description | BACKGROUND: A sputum culture is the most reliable indicator of the infectiousness of pulmonary tuberculosis (PTB); however, a spontaneous sputum specimen may not be suitable. The aim of this study was to evaluate the infectious period in patients with non–drug-resistant (DR) PTB receiving adequate standard chemotherapy, using induced sputum (IS) specimens. METHODS: We evaluated the duration of infectiousness of PTB using a retrospective cohort design. RESULTS: Among the 35 patients with PTB, 22 were smear-positive. The rates of IS culture positivity from baseline to the sixth week of anti-tuberculosis medication in the smear-positive PTB group were 100%, 100%, 91%, 73%, 36%, and 18%, respectively. For smear-positive PTB cases, the median time of conversion to culture negativity was 35.0 days (range, 28.0–42.0 days). In the smear-negative PTB group (n=13), the weekly rates of positive IS culture were 100%, 77%, 39%, 8%, 0%, and 0%, respectively, and the median time to conversion to culture-negative was 21.0 days (range, 17.5–28.0 days). CONCLUSION: The infectiousness of PTB, under adequate therapy, may persist longer than previously reported, even in patients with non-DR PTB. |
format | Online Article Text |
id | pubmed-5256343 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | The Korean Academy of Tuberculosis and Respiratory Diseases |
record_format | MEDLINE/PubMed |
spelling | pubmed-52563432017-01-24 Duration of Pulmonary Tuberculosis Infectiousness under Adequate Therapy, as Assessed Using Induced Sputum Samples Ko, Yousang Shin, Jeong Hwan Lee, Hyun-Kyung Lee, Young Seok Lee, Suh-Young Park, So Young Mo, Eun-Kyung Kim, Changhwan Park, Yong Bum Tuberc Respir Dis (Seoul) Original Article BACKGROUND: A sputum culture is the most reliable indicator of the infectiousness of pulmonary tuberculosis (PTB); however, a spontaneous sputum specimen may not be suitable. The aim of this study was to evaluate the infectious period in patients with non–drug-resistant (DR) PTB receiving adequate standard chemotherapy, using induced sputum (IS) specimens. METHODS: We evaluated the duration of infectiousness of PTB using a retrospective cohort design. RESULTS: Among the 35 patients with PTB, 22 were smear-positive. The rates of IS culture positivity from baseline to the sixth week of anti-tuberculosis medication in the smear-positive PTB group were 100%, 100%, 91%, 73%, 36%, and 18%, respectively. For smear-positive PTB cases, the median time of conversion to culture negativity was 35.0 days (range, 28.0–42.0 days). In the smear-negative PTB group (n=13), the weekly rates of positive IS culture were 100%, 77%, 39%, 8%, 0%, and 0%, respectively, and the median time to conversion to culture-negative was 21.0 days (range, 17.5–28.0 days). CONCLUSION: The infectiousness of PTB, under adequate therapy, may persist longer than previously reported, even in patients with non-DR PTB. The Korean Academy of Tuberculosis and Respiratory Diseases 2017-01 2016-12-30 /pmc/articles/PMC5256343/ /pubmed/28119744 http://dx.doi.org/10.4046/trd.2017.80.1.27 Text en Copyright©2017. The Korean Academy of Tuberculosis and Respiratory Diseases. All rights reserved. http://creativecommons.org/licenses/by-nc/4.0/ It is identical to the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) |
spellingShingle | Original Article Ko, Yousang Shin, Jeong Hwan Lee, Hyun-Kyung Lee, Young Seok Lee, Suh-Young Park, So Young Mo, Eun-Kyung Kim, Changhwan Park, Yong Bum Duration of Pulmonary Tuberculosis Infectiousness under Adequate Therapy, as Assessed Using Induced Sputum Samples |
title | Duration of Pulmonary Tuberculosis Infectiousness under Adequate Therapy, as Assessed Using Induced Sputum Samples |
title_full | Duration of Pulmonary Tuberculosis Infectiousness under Adequate Therapy, as Assessed Using Induced Sputum Samples |
title_fullStr | Duration of Pulmonary Tuberculosis Infectiousness under Adequate Therapy, as Assessed Using Induced Sputum Samples |
title_full_unstemmed | Duration of Pulmonary Tuberculosis Infectiousness under Adequate Therapy, as Assessed Using Induced Sputum Samples |
title_short | Duration of Pulmonary Tuberculosis Infectiousness under Adequate Therapy, as Assessed Using Induced Sputum Samples |
title_sort | duration of pulmonary tuberculosis infectiousness under adequate therapy, as assessed using induced sputum samples |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5256343/ https://www.ncbi.nlm.nih.gov/pubmed/28119744 http://dx.doi.org/10.4046/trd.2017.80.1.27 |
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