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Morphological Transformation and Force Generation of Active Cytoskeletal Networks

Cells assemble numerous types of actomyosin bundles that generate contractile forces for biological processes, such as cytokinesis and cell migration. One example of contractile bundles is a transverse arc that forms via actomyosin-driven condensation of actin filaments in the lamellipodia of migrat...

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Autores principales: Bidone, Tamara Carla, Jung, Wonyeong, Maruri, Daniel, Borau, Carlos, Kamm, Roger D., Kim, Taeyoon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5256887/
https://www.ncbi.nlm.nih.gov/pubmed/28114384
http://dx.doi.org/10.1371/journal.pcbi.1005277
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author Bidone, Tamara Carla
Jung, Wonyeong
Maruri, Daniel
Borau, Carlos
Kamm, Roger D.
Kim, Taeyoon
author_facet Bidone, Tamara Carla
Jung, Wonyeong
Maruri, Daniel
Borau, Carlos
Kamm, Roger D.
Kim, Taeyoon
author_sort Bidone, Tamara Carla
collection PubMed
description Cells assemble numerous types of actomyosin bundles that generate contractile forces for biological processes, such as cytokinesis and cell migration. One example of contractile bundles is a transverse arc that forms via actomyosin-driven condensation of actin filaments in the lamellipodia of migrating cells and exerts significant forces on the surrounding environments. Structural reorganization of a network into a bundle facilitated by actomyosin contractility is a physiologically relevant and biophysically interesting process. Nevertheless, it remains elusive how actin filaments are reoriented, buckled, and bundled as well as undergo tension buildup during the structural reorganization. In this study, using an agent-based computational model, we demonstrated how the interplay between the density of myosin motors and cross-linking proteins and the rigidity, initial orientation, and turnover of actin filaments regulates the morphological transformation of a cross-linked actomyosin network into a bundle and the buildup of tension occurring during the transformation.
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spelling pubmed-52568872017-02-06 Morphological Transformation and Force Generation of Active Cytoskeletal Networks Bidone, Tamara Carla Jung, Wonyeong Maruri, Daniel Borau, Carlos Kamm, Roger D. Kim, Taeyoon PLoS Comput Biol Research Article Cells assemble numerous types of actomyosin bundles that generate contractile forces for biological processes, such as cytokinesis and cell migration. One example of contractile bundles is a transverse arc that forms via actomyosin-driven condensation of actin filaments in the lamellipodia of migrating cells and exerts significant forces on the surrounding environments. Structural reorganization of a network into a bundle facilitated by actomyosin contractility is a physiologically relevant and biophysically interesting process. Nevertheless, it remains elusive how actin filaments are reoriented, buckled, and bundled as well as undergo tension buildup during the structural reorganization. In this study, using an agent-based computational model, we demonstrated how the interplay between the density of myosin motors and cross-linking proteins and the rigidity, initial orientation, and turnover of actin filaments regulates the morphological transformation of a cross-linked actomyosin network into a bundle and the buildup of tension occurring during the transformation. Public Library of Science 2017-01-23 /pmc/articles/PMC5256887/ /pubmed/28114384 http://dx.doi.org/10.1371/journal.pcbi.1005277 Text en © 2017 Bidone et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Bidone, Tamara Carla
Jung, Wonyeong
Maruri, Daniel
Borau, Carlos
Kamm, Roger D.
Kim, Taeyoon
Morphological Transformation and Force Generation of Active Cytoskeletal Networks
title Morphological Transformation and Force Generation of Active Cytoskeletal Networks
title_full Morphological Transformation and Force Generation of Active Cytoskeletal Networks
title_fullStr Morphological Transformation and Force Generation of Active Cytoskeletal Networks
title_full_unstemmed Morphological Transformation and Force Generation of Active Cytoskeletal Networks
title_short Morphological Transformation and Force Generation of Active Cytoskeletal Networks
title_sort morphological transformation and force generation of active cytoskeletal networks
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5256887/
https://www.ncbi.nlm.nih.gov/pubmed/28114384
http://dx.doi.org/10.1371/journal.pcbi.1005277
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