Cargando…

Targeted Sequencing of Lung Function Loci in Chronic Obstructive Pulmonary Disease Cases and Controls

Chronic obstructive pulmonary disease (COPD) is the third leading cause of death worldwide; smoking is the main risk factor for COPD, but genetic factors are also relevant contributors. Genome-wide association studies (GWAS) of the lung function measures used in the diagnosis of COPD have identified...

Descripción completa

Detalles Bibliográficos
Autores principales:	Artigas, María Soler, Wain, Louise V., Shrine, Nick, McKeever, Tricia M., Sayers, Ian, Hall, Ian P., Tobin, Martin D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5256917/ https://www.ncbi.nlm.nih.gov/pubmed/28114305 http://dx.doi.org/10.1371/journal.pone.0170222

Ejemplares similares

Copy Number Variation of the Beta-Defensin Genes in Europeans: No Supporting Evidence for Association with Lung Function, Chronic Obstructive Pulmonary Disease or Asthma
por: Wain, Louise V., et al.
Publicado: (2014)

Whole Exome Re-Sequencing Implicates CCDC38 and Cilia Structure and Function in Resistance to Smoking Related Airflow Obstruction
por: Wain, Louise V., et al.
Publicado: (2014)

Mendelian randomisation of eosinophils and other cell types in relation to lung function and disease
por: Guyatt, Anna, et al.
Publicado: (2023)

Novel insights into the genetics of smoking behaviour, lung function, and chronic obstructive pulmonary disease (UK BiLEVE): a genetic association study in UK Biobank
por: Wain, Louise V, et al.
Publicado: (2015)

Genome-wide association study of chronic sputum production implicates loci involved in mucus production and infection
por: Packer, Richard J., et al.
Publicado: (2023)

Predicting fracture risk in patients with chronic obstructive pulmonary disease: a UK-based population-based cohort study
por: Akyea, Ralph Kwame, et al.
Publicado: (2019)

Haplotype estimation for biobank scale datasets
por: O’Connell, Jared, et al.
Publicado: (2016)

Genome-wide association analyses for lung function and chronic obstructive pulmonary disease identify new loci and potential druggable targets
por: Wain, Louise V, et al.
Publicado: (2017)

Exome-wide analysis of copy number variation shows association of the human leukocyte antigen region with asthma in UK Biobank
por: Fawcett, Katherine A., et al.
Publicado: (2022)

Genetic variants affecting cross-sectional lung function in adults show little or no effect on longitudinal lung function decline
por: John, Catherine, et al.
Publicado: (2017)

The Association between Systemic Inflammatory Cellular Levels and Lung Function: A Population-Based Study
por: McKeever, Tricia, et al.
Publicado: (2011)

Genome-wide gene-air pollution interaction analysis of lung function in 300,000 individuals
por: Melbourne, Carl A., et al.
Publicado: (2022)

Refining Susceptibility Loci of Chronic Obstructive Pulmonary Disease with Lung eqtls
por: Lamontagne, Maxime, et al.
Publicado: (2013)

GSTCD and INTS12 Regulation and Expression in the Human Lung
por: Obeidat, Ma’en, et al.
Publicado: (2013)

The recording and characteristics of pulmonary rehabilitation in patients with COPD using The Health Information Network (THIN) primary care database
por: Hakamy, Ali, et al.
Publicado: (2017)

Effect of implementing the NEWS2 escalation protocol in a large acute NHS trust: a retrospective cohort analysis of mortality, workload and ability of early warning score to predict death within 24 hours
por: Forster, Sarah, et al.
Publicado: (2022)

The use of the practice walk test in pulmonary rehabilitation program: National COPD Audit Pulmonary Rehabilitation Workstream
por: Hakamy, Ali, et al.
Publicado: (2017)

Place of Death in Patients with Lung Cancer: A Retrospective Cohort Study from 2004-2013
por: O’Dowd, Emma L., et al.
Publicado: (2016)

Human CCL3L1 copy number variation, gene expression, and the role of the CCL3L1-CCR5 axis in lung function
por: Adewoye, Adeolu B., et al.
Publicado: (2018)

Management of Fracture Risk in Patients with Chronic Obstructive Pulmonary Disease (COPD): Building a UK Consensus Through Healthcare Professional and Patient Engagement
por: Gupta, Ayushman, et al.
Publicado: (2020)

Non-invasive pneumococcal pneumonia due to vaccine serotypes: A systematic review and meta-analysis
por: Lansbury, Louise, et al.
Publicado: (2022)

Impact of social deprivation on clinical outcomes of adults hospitalised with community-acquired pneumonia in England: a retrospective cohort study
por: Lawrence, Hannah, et al.
Publicado: (2022)

Age at menarche and lung function: a Mendelian randomization study
por: Gill, Dipender, et al.
Publicado: (2017)

A multivariate analysis of serum nutrient levels and lung function
por: McKeever, Tricia M, et al.
Publicado: (2008)

Moderate-to-severe asthma in individuals of European ancestry: a genome-wide association study
por: Shrine, Nick, et al.
Publicado: (2019)

A retrospective database study of oral corticosteroid and bisphosphonate prescribing patterns in England
por: Chalitsios, Christos V., et al.
Publicado: (2020)

New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries.
por: Shrine, Nick, et al.
Publicado: (2019)

The Its Not JUST Idiopathic pulmonary fibrosis Study (INJUSTIS): description of the protocol for a multicentre prospective observational cohort study identifying biomarkers of progressive fibrotic lung disease
por: Khan, Fasihul, et al.
Publicado: (2019)

Investigating the discriminative value of Early Warning Scores in patients with respiratory disease using a retrospective cohort analysis of admissions to Nottingham University Hospitals Trust over a 2-year period
por: Forster, Sarah, et al.
Publicado: (2018)

Chronic obstructive pulmonary disease and related phenotypes: polygenic risk scores in population-based and case-control cohorts
por: Moll, Matthew, et al.
Publicado: (2020)

The Association Between Blood Coagulation Activity and Lung Function: A Population-Based Study
por: Fogarty, Andrew W., et al.
Publicado: (2010)

The incidence of and mortality from leukaemias in the UK: a general population-based study
por: Bhayat, Fatima, et al.
Publicado: (2009)

Cerebrovascular accident and acute coronary syndrome and perioperative outcomes (CAPO) study protocol: a 10-year database linkage between Hospital Episode Statistics Admitted Patient Care, Myocardial Infarction National Audit Project and Office for National Statistics registries for time-dependent risk analysis of perioperative outcomes in English NHS hospitals
por: Luney, Matthew Stephen, et al.
Publicado: (2020)

Impact of Coexisting Dementia on Inpatient Outcomes for Patients Admitted with a COPD Exacerbation
por: Gupta, Ayushman, et al.
Publicado: (2022)

Phenotypic and functional translation of IL1RL1 locus polymorphisms in lung tissue and asthmatic airway epithelium
por: Portelli, Michael A., et al.
Publicado: (2020)

The acute impact of a hematopoietic allograft on lung function and inflammation: a prospective observational study
por: Enocson, Alexandra, et al.
Publicado: (2013)

Interaction of Cigarette Smoking and Polygenic Risk Score on Reduced Lung Function
por: Kim, Woori, et al.
Publicado: (2021)

Changes in targeted metabolomics in lung tissue of chronic obstructive pulmonary disease
por: Feng, Yi, et al.
Publicado: (2023)

Qualitative study of user perspectives and experiences of digital inhaler technology
por: Adejumo, Ireti, et al.
Publicado: (2022)

Genome-wide association study of copy number variation with lung function identifies a novel signal of association near BANP for forced vital capacity
por: Shrine, Nick, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_3vi2evfeefmpe334ok3vt4ecks