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DNA Methylation Changes in Valproic Acid-Treated HeLa Cells as Assessed by Image Analysis, Immunofluorescence and Vibrational Microspectroscopy

Valproic acid (VPA), a well-known histone deacetylase inhibitor, has been reported to affect the DNA methylation status in addition to inducing histone hyperacetylation in several cell types. In HeLa cells, VPA promotes histone acetylation and chromatin remodeling. However, DNA demethylation was not...

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Detalles Bibliográficos
Autores principales:	Veronezi, Giovana M. B., Felisbino, Marina Barreto, Gatti, Maria Sílvia V., Mello, Maria Luiza S., Vidal, Benedicto de Campos
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5256918/ https://www.ncbi.nlm.nih.gov/pubmed/28114349 http://dx.doi.org/10.1371/journal.pone.0170740

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