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Altered Microstructural Caudate Integrity in Posttraumatic Stress Disorder but Not Traumatic Brain Injury

OBJECTIVE: Given the high prevalence and comorbidity of combat-related PTSD and TBI in Veterans, it is often difficult to disentangle the contributions of each disorder. Examining these pathologies separately may help to understand the neurobiological basis of memory impairment in PTSD and TBI indep...

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Autores principales: Waltzman, Dana, Soman, Salil, Hantke, Nathan C., Fairchild, J. Kaci, Kinoshita, Lisa M., Wintermark, Max, Ashford, J. Wesson, Yesavage, Jerome, Williams, Leanne, Adamson, Maheen M., Furst, Ansgar J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5256941/
https://www.ncbi.nlm.nih.gov/pubmed/28114393
http://dx.doi.org/10.1371/journal.pone.0170564
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author Waltzman, Dana
Soman, Salil
Hantke, Nathan C.
Fairchild, J. Kaci
Kinoshita, Lisa M.
Wintermark, Max
Ashford, J. Wesson
Yesavage, Jerome
Williams, Leanne
Adamson, Maheen M.
Furst, Ansgar J.
author_facet Waltzman, Dana
Soman, Salil
Hantke, Nathan C.
Fairchild, J. Kaci
Kinoshita, Lisa M.
Wintermark, Max
Ashford, J. Wesson
Yesavage, Jerome
Williams, Leanne
Adamson, Maheen M.
Furst, Ansgar J.
author_sort Waltzman, Dana
collection PubMed
description OBJECTIVE: Given the high prevalence and comorbidity of combat-related PTSD and TBI in Veterans, it is often difficult to disentangle the contributions of each disorder. Examining these pathologies separately may help to understand the neurobiological basis of memory impairment in PTSD and TBI independently of each other. Thus, we investigated whether a) PTSD and TBI are characterized by subcortical structural abnormalities by examining diffusion tensor imaging (DTI) metrics and volume and b) if these abnormalities were specific to PTSD versus TBI. METHOD: We investigated whether individuals with PTSD or TBI display subcortical structural abnormalities in memory regions by examining DTI metrics and volume of the hippocampus and caudate in three groups of Veterans: Veterans with PTSD, Veterans with TBI, and Veterans with neither PTSD nor TBI (Veteran controls). RESULTS: While our results demonstrated no macrostructural differences among the groups in these regions, there were significant alterations in microstructural DTI indices in the caudate for the PTSD group but not the TBI group compared to Veteran controls. CONCLUSIONS: The result of increased mean, radial, and axial diffusivity, and decreased fractional anisotropy in the caudate in absence of significant volume atrophy in the PTSD group suggests the presence of subtle abnormalities evident only at a microstructural level. The caudate is thought to play a role in the physiopathology of PTSD, and the habit-like behavioral features of the disorder could be due to striatal-dependent habit learning mechanisms. Thus, DTI appears to be a vital tool to investigate subcortical pathology, greatly enhancing the ability to detect subtle brain changes in complex disorders.
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spelling pubmed-52569412017-02-06 Altered Microstructural Caudate Integrity in Posttraumatic Stress Disorder but Not Traumatic Brain Injury Waltzman, Dana Soman, Salil Hantke, Nathan C. Fairchild, J. Kaci Kinoshita, Lisa M. Wintermark, Max Ashford, J. Wesson Yesavage, Jerome Williams, Leanne Adamson, Maheen M. Furst, Ansgar J. PLoS One Research Article OBJECTIVE: Given the high prevalence and comorbidity of combat-related PTSD and TBI in Veterans, it is often difficult to disentangle the contributions of each disorder. Examining these pathologies separately may help to understand the neurobiological basis of memory impairment in PTSD and TBI independently of each other. Thus, we investigated whether a) PTSD and TBI are characterized by subcortical structural abnormalities by examining diffusion tensor imaging (DTI) metrics and volume and b) if these abnormalities were specific to PTSD versus TBI. METHOD: We investigated whether individuals with PTSD or TBI display subcortical structural abnormalities in memory regions by examining DTI metrics and volume of the hippocampus and caudate in three groups of Veterans: Veterans with PTSD, Veterans with TBI, and Veterans with neither PTSD nor TBI (Veteran controls). RESULTS: While our results demonstrated no macrostructural differences among the groups in these regions, there were significant alterations in microstructural DTI indices in the caudate for the PTSD group but not the TBI group compared to Veteran controls. CONCLUSIONS: The result of increased mean, radial, and axial diffusivity, and decreased fractional anisotropy in the caudate in absence of significant volume atrophy in the PTSD group suggests the presence of subtle abnormalities evident only at a microstructural level. The caudate is thought to play a role in the physiopathology of PTSD, and the habit-like behavioral features of the disorder could be due to striatal-dependent habit learning mechanisms. Thus, DTI appears to be a vital tool to investigate subcortical pathology, greatly enhancing the ability to detect subtle brain changes in complex disorders. Public Library of Science 2017-01-23 /pmc/articles/PMC5256941/ /pubmed/28114393 http://dx.doi.org/10.1371/journal.pone.0170564 Text en https://creativecommons.org/publicdomain/zero/1.0/ This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 (https://creativecommons.org/publicdomain/zero/1.0/) public domain dedication.
spellingShingle Research Article
Waltzman, Dana
Soman, Salil
Hantke, Nathan C.
Fairchild, J. Kaci
Kinoshita, Lisa M.
Wintermark, Max
Ashford, J. Wesson
Yesavage, Jerome
Williams, Leanne
Adamson, Maheen M.
Furst, Ansgar J.
Altered Microstructural Caudate Integrity in Posttraumatic Stress Disorder but Not Traumatic Brain Injury
title Altered Microstructural Caudate Integrity in Posttraumatic Stress Disorder but Not Traumatic Brain Injury
title_full Altered Microstructural Caudate Integrity in Posttraumatic Stress Disorder but Not Traumatic Brain Injury
title_fullStr Altered Microstructural Caudate Integrity in Posttraumatic Stress Disorder but Not Traumatic Brain Injury
title_full_unstemmed Altered Microstructural Caudate Integrity in Posttraumatic Stress Disorder but Not Traumatic Brain Injury
title_short Altered Microstructural Caudate Integrity in Posttraumatic Stress Disorder but Not Traumatic Brain Injury
title_sort altered microstructural caudate integrity in posttraumatic stress disorder but not traumatic brain injury
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5256941/
https://www.ncbi.nlm.nih.gov/pubmed/28114393
http://dx.doi.org/10.1371/journal.pone.0170564
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