Polyporus squamosus Lectin 1a (PSL1a) Exhibits Cytotoxicity in Mammalian Cells by Disruption of Focal Adhesions, Inhibition of Protein Synthesis and Induction of Apoptosis

PSL1a is a lectin from the mushroom Polyporus squamosus that binds to sialylated glycans and glycoconjugates with high specificity and selectivity. In addition to its N-terminal carbohydrate-binding domain, PSL1a possesses a Ca(2+)-dependent proteolytic activity in the C-terminal domain. In the pres...

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Detalles Bibliográficos
Autores principales: Manna, Dipankar, Pust, Sascha, Torgersen, Maria L., Cordara, Gabriele, Künzler, Markus, Krengel, Ute, Sandvig, Kirsten
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5256987/
https://www.ncbi.nlm.nih.gov/pubmed/28114329
http://dx.doi.org/10.1371/journal.pone.0170716

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