Identification and Whole Genome Sequencing of the First Case of Kosakonia radicincitans Causing a Human Bloodstream Infection

The taxonomy of Enterobacter species is rapidly changing. Herein we report a bloodstream infection isolate originally identified as Enterobacter cloacae by Vitek2 methodology that we found to be Kosakonia radicincitans using genetic means. Comparative whole genome sequencing of our isolate and other...

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Autores principales: Bhatti, Micah D., Kalia, Awdhesh, Sahasrabhojane, Pranoti, Kim, Jiwoong, Greenberg, David E., Shelburne, Samuel A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5258702/
https://www.ncbi.nlm.nih.gov/pubmed/28174569
http://dx.doi.org/10.3389/fmicb.2017.00062
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author Bhatti, Micah D.
Kalia, Awdhesh
Sahasrabhojane, Pranoti
Kim, Jiwoong
Greenberg, David E.
Shelburne, Samuel A.
author_facet Bhatti, Micah D.
Kalia, Awdhesh
Sahasrabhojane, Pranoti
Kim, Jiwoong
Greenberg, David E.
Shelburne, Samuel A.
author_sort Bhatti, Micah D.
collection PubMed
description The taxonomy of Enterobacter species is rapidly changing. Herein we report a bloodstream infection isolate originally identified as Enterobacter cloacae by Vitek2 methodology that we found to be Kosakonia radicincitans using genetic means. Comparative whole genome sequencing of our isolate and other published Kosakonia genomes revealed these organisms lack the AmpC β-lactamase present on the chromosome of Enterobacter sp. A fimbriae operon primarily found in Escherichia coli O157:H7 isolates was present in our organism and other available K. radicincitans genomes. This is the first report of a Kosakonia species, which are typically associated with plants, causing a human infection.
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spelling pubmed-52587022017-02-07 Identification and Whole Genome Sequencing of the First Case of Kosakonia radicincitans Causing a Human Bloodstream Infection Bhatti, Micah D. Kalia, Awdhesh Sahasrabhojane, Pranoti Kim, Jiwoong Greenberg, David E. Shelburne, Samuel A. Front Microbiol Microbiology The taxonomy of Enterobacter species is rapidly changing. Herein we report a bloodstream infection isolate originally identified as Enterobacter cloacae by Vitek2 methodology that we found to be Kosakonia radicincitans using genetic means. Comparative whole genome sequencing of our isolate and other published Kosakonia genomes revealed these organisms lack the AmpC β-lactamase present on the chromosome of Enterobacter sp. A fimbriae operon primarily found in Escherichia coli O157:H7 isolates was present in our organism and other available K. radicincitans genomes. This is the first report of a Kosakonia species, which are typically associated with plants, causing a human infection. Frontiers Media S.A. 2017-01-24 /pmc/articles/PMC5258702/ /pubmed/28174569 http://dx.doi.org/10.3389/fmicb.2017.00062 Text en Copyright © 2017 Bhatti, Kalia, Sahasrabhojane, Kim, Greenberg and Shelburne. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Microbiology
Bhatti, Micah D.
Kalia, Awdhesh
Sahasrabhojane, Pranoti
Kim, Jiwoong
Greenberg, David E.
Shelburne, Samuel A.
Identification and Whole Genome Sequencing of the First Case of Kosakonia radicincitans Causing a Human Bloodstream Infection
title Identification and Whole Genome Sequencing of the First Case of Kosakonia radicincitans Causing a Human Bloodstream Infection
title_full Identification and Whole Genome Sequencing of the First Case of Kosakonia radicincitans Causing a Human Bloodstream Infection
title_fullStr Identification and Whole Genome Sequencing of the First Case of Kosakonia radicincitans Causing a Human Bloodstream Infection
title_full_unstemmed Identification and Whole Genome Sequencing of the First Case of Kosakonia radicincitans Causing a Human Bloodstream Infection
title_short Identification and Whole Genome Sequencing of the First Case of Kosakonia radicincitans Causing a Human Bloodstream Infection
title_sort identification and whole genome sequencing of the first case of kosakonia radicincitans causing a human bloodstream infection
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5258702/
https://www.ncbi.nlm.nih.gov/pubmed/28174569
http://dx.doi.org/10.3389/fmicb.2017.00062
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