Cargando…

A Practical Guide to Approaching Biased Agonism at G Protein Coupled Receptors

Biased agonism, the ability of a receptor to differentially activate downstream signaling pathways depending on binding of a “biased” agonist compared to a “balanced” agonist, is a well-established paradigm for G protein-coupled receptor (GPCR) signaling. Biased agonists have the promise to act as s...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gundry, Jaimee, Glenn, Rachel, Alagesan, Priya, Rajagopal, Sudarshan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2017
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5258729/ https://www.ncbi.nlm.nih.gov/pubmed/28174517 http://dx.doi.org/10.3389/fnins.2017.00017

Ejemplares similares

Modelling and simulation of biased agonism dynamics at a G protein-coupled receptor
por: Bridge, L.J., et al.
Publicado: (2018)

Structural Insights into Ligand—Receptor Interactions Involved in Biased Agonism of G-Protein Coupled Receptors
por: Jóźwiak, Krzysztof, et al.
Publicado: (2021)

The Biased G-Protein-Coupled Receptor Agonism Bridges the Gap between the Insulin Receptor and the Metabolic Syndrome
por: Liauchonak, Iryna, et al.
Publicado: (2018)

Biased agonism
por: Kenakin, Terry
Publicado: (2009)

Conformational signatures in β-arrestin2 reveal natural biased agonism at a G-protein-coupled receptor
por: Reyes-Alcaraz, Arfaxad, et al.
Publicado: (2018)

Editorial: Recent Advances in G Protein-Coupled Receptor Signalling: Impact of Intracellular Location, Environment and Biased Agonism
por: Halls, Michelle L., et al.
Publicado: (2021)

Systematic errors in detecting biased agonism: Analysis of current methods and development of a new model-free approach
por: Onaran, H. Ongun, et al.
Publicado: (2017)

G protein stoichiometry dictates biased agonism through distinct receptor-G protein partitioning
por: Onfroy, Lauriane, et al.
Publicado: (2017)

The therapeutic potential of GLP‐1 receptor biased agonism
por: Jones, Ben
Publicado: (2021)

A structural mechanism of nuclear receptor biased agonism
por: Nemetchek, Michelle D., et al.
Publicado: (2022)

Ligand recognition and biased agonism of the D1 dopamine receptor
por: Teng, Xiao, et al.
Publicado: (2022)

A Pharmacological Primer of Biased Agonism
por: Andresen, Bradley T
Publicado: (2011)

Biased agonism: the quest for the analgesic holy grail
por: Stanczyk, M. Alexander, et al.
Publicado: (2018)

Molecular mechanism of agonism and inverse agonism in ghrelin receptor
por: Qin, Jiao, et al.
Publicado: (2022)

The Role of G Protein-Coupled Receptors in the Right Ventricle in Pulmonary Hypertension
por: Viswanathan, Gayathri, et al.
Publicado: (2018)

Biased Agonism of Three Different Cannabinoid Receptor Agonists in Mouse Brain Cortex
por: Diez-Alarcia, Rebeca, et al.
Publicado: (2016)

The Extracellular Surface of the GLP-1 Receptor Is a Molecular Trigger for Biased Agonism
por: Wootten, Denise, et al.
Publicado: (2016)

The role of kinetic context in apparent biased agonism at GPCRs
por: Klein Herenbrink, Carmen, et al.
Publicado: (2016)

Arrestin-biased AT1R agonism induces acute catecholamine secretion through TRPC3 coupling
por: Liu, Chun-Hua, et al.
Publicado: (2017)

Influence of Chemokine N-Terminal Modification on Biased Agonism at the Chemokine Receptor CCR1
por: Sanchez, Julie, et al.
Publicado: (2019)

Characterisation of inverse agonism of the orphan-G protein-coupled receptor GPR52 by cannabinoid ligands Cannabidiol and O-1918
por: Stott, Lisa A., et al.
Publicado: (2021)

Agonism and Antagonism at the Insulin Receptor
por: Knudsen, Louise, et al.
Publicado: (2012)

Biased versus Partial Agonism in the Search for Safer Opioid Analgesics
por: Azevedo Neto, Joaquim, et al.
Publicado: (2020)

The Old and New Visions of Biased Agonism Through the Prism of Adenosine Receptor Signaling and Receptor/Receptor and Receptor/Protein Interactions
por: Franco, Rafael, et al.
Publicado: (2021)

Human Luteinizing Hormone and Chorionic Gonadotropin Display Biased Agonism at the LH and LH/CG Receptors
por: Riccetti, Laura, et al.
Publicado: (2017)

Quantitative Systems Pharmacology and Biased Agonism at Opioid Receptors: A Potential Avenue for Improved Analgesics
por: Bedini, Andrea, et al.
Publicado: (2022)

Loss of Choline Agonism in the Inner Ear Hair Cell Nicotinic Acetylcholine Receptor Linked to the α10 Subunit
por: Moglie, Marcelo J., et al.
Publicado: (2021)

Both Ligand- and Cell-Specific Parameters Control Ligand Agonism in a Kinetic Model of G Protein–Coupled Receptor Signaling
por: Kinzer-Ursem, Tamara L, et al.
Publicado: (2007)

Agonal Factors Distort Gene-Expression Patterns in Human Postmortem Brains
por: Dai, Jiacheng, et al.
Publicado: (2021)

Molecular basis for allosteric agonism and G protein subtype selectivity of galanin receptors
por: Duan, Jia, et al.
Publicado: (2022)

A Complementary Scale of Biased Agonism for Agonists with Differing Maximal Responses
por: Burgueño, Javier, et al.
Publicado: (2017)

Presynaptic G Protein-Coupled Receptors: Gatekeepers of Addiction?
por: Johnson, Kari A., et al.
Publicado: (2016)

Enterohepatic Takeda G-Protein Coupled Receptor 5 Agonism in Metabolic Dysfunction-Associated Fatty Liver Disease and Related Glucose Dysmetabolism
por: Gillard, Justine, et al.
Publicado: (2022)

G(i/o)-Protein Coupled Receptors in the Aging Brain
por: de Oliveira, Patrícia G., et al.
Publicado: (2019)

Acute Corticotropin-Releasing Factor Receptor Type 2 Agonism Results in Sustained Symptom Improvement in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
por: Pereira, Gerard, et al.
Publicado: (2021)

Exploring Biased Agonism at FPR1 as a Means to Encode Danger Sensing †
por: Gröper, Jieny, et al.
Publicado: (2020)

Structure-Activity Investigation of a G Protein-Biased Agonist Reveals Molecular Determinants for Biased Signaling of the D(2) Dopamine Receptor
por: Chun, Lani S., et al.
Publicado: (2018)

Kinetic basis of partial agonism at NMDA receptors
por: Kussius, Cassandra L, et al.
Publicado: (2009)

Agonizing Hedgehog
por: Weitzman, Jonathan B
Publicado: (2002)

A Bright and Colorful Future for G-Protein Coupled Receptor Sensors
por: Ravotto, Luca, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_c2nsu11evujha1as2vrrc72eq7