Deletion of the Chemokine Binding Protein Gene from the Parapoxvirus Orf Virus Reduces Virulence and Pathogenesis in Sheep

Orf virus (ORFV) is the type species of the Parapoxvirus genus of the family Poxviridae and infects sheep and goats, often around the mouth, resulting in acute pustular skin lesions. ORFV encodes several secreted immunomodulators including a broad-spectrum chemokine binding protein (CBP). Chemokines...

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Detalles Bibliográficos
Autores principales: Fleming, Stephen B., McCaughan, Catherine, Lateef, Zabeen, Dunn, Amy, Wise, Lyn M., Real, Nicola C., Mercer, Andrew A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5258736/
https://www.ncbi.nlm.nih.gov/pubmed/28174562
http://dx.doi.org/10.3389/fmicb.2017.00046

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