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Regulation of Connexin-Based Channels by Fatty Acids
In this mini-review, we briefly summarize the current knowledge about the effects of fatty acids (FAs) on connexin-based channels, as well as discuss the limited information about the impact FAs may have on pannexins (Panxs). FAs regulate diverse cellular functions, some of which are explained by ch...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5258758/ https://www.ncbi.nlm.nih.gov/pubmed/28174541 http://dx.doi.org/10.3389/fphys.2017.00011 |
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author | Puebla, Carlos Retamal, Mauricio A. Acuña, Rodrigo Sáez, Juan C. |
author_facet | Puebla, Carlos Retamal, Mauricio A. Acuña, Rodrigo Sáez, Juan C. |
author_sort | Puebla, Carlos |
collection | PubMed |
description | In this mini-review, we briefly summarize the current knowledge about the effects of fatty acids (FAs) on connexin-based channels, as well as discuss the limited information about the impact FAs may have on pannexins (Panxs). FAs regulate diverse cellular functions, some of which are explained by changes in the activity of channels constituted by connexins (Cxs) or Panxs, which are known to play critical roles in maintaining the functional integrity of diverse organs and tissues. Cxs are transmembrane proteins that oligomerize into hexamers to form hemichannels (HCs), which in turn can assemble into dodecamers to form gap junction channels (GJCs). While GJCs communicate the cytoplasm of contacting cells, HCs serve as pathways for the exchange of ions and small molecules between the intra and extracellular milieu. Panxs, as well as Cx HCs, form channels at the plasma membrane that enable the interchange of molecules between the intra and extracellular spaces. Both Cx- and Panx-based channels are controlled by several post-translational modifications. However, the mechanism of action of FAs on these channels has not been described in detail. It has been shown however that FAs frequently decrease GJC-mediated cell-cell communication. The opposite effect also has been described for HC or Panx-dependent intercellular communication, where, the acute FA effect can be reversed upon washout. Additionally, changes in GJCs mediated by FAs have been associated with post-translational modifications (e.g., phosphorylation), and seem to be directly related to chemical properties of FAs (e.g., length of carbon chain and/or degree of saturation), but this possible link remains poorly understood. |
format | Online Article Text |
id | pubmed-5258758 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-52587582017-02-07 Regulation of Connexin-Based Channels by Fatty Acids Puebla, Carlos Retamal, Mauricio A. Acuña, Rodrigo Sáez, Juan C. Front Physiol Physiology In this mini-review, we briefly summarize the current knowledge about the effects of fatty acids (FAs) on connexin-based channels, as well as discuss the limited information about the impact FAs may have on pannexins (Panxs). FAs regulate diverse cellular functions, some of which are explained by changes in the activity of channels constituted by connexins (Cxs) or Panxs, which are known to play critical roles in maintaining the functional integrity of diverse organs and tissues. Cxs are transmembrane proteins that oligomerize into hexamers to form hemichannels (HCs), which in turn can assemble into dodecamers to form gap junction channels (GJCs). While GJCs communicate the cytoplasm of contacting cells, HCs serve as pathways for the exchange of ions and small molecules between the intra and extracellular milieu. Panxs, as well as Cx HCs, form channels at the plasma membrane that enable the interchange of molecules between the intra and extracellular spaces. Both Cx- and Panx-based channels are controlled by several post-translational modifications. However, the mechanism of action of FAs on these channels has not been described in detail. It has been shown however that FAs frequently decrease GJC-mediated cell-cell communication. The opposite effect also has been described for HC or Panx-dependent intercellular communication, where, the acute FA effect can be reversed upon washout. Additionally, changes in GJCs mediated by FAs have been associated with post-translational modifications (e.g., phosphorylation), and seem to be directly related to chemical properties of FAs (e.g., length of carbon chain and/or degree of saturation), but this possible link remains poorly understood. Frontiers Media S.A. 2017-01-24 /pmc/articles/PMC5258758/ /pubmed/28174541 http://dx.doi.org/10.3389/fphys.2017.00011 Text en Copyright © 2017 Puebla, Retamal, Acuña and Sáez. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Physiology Puebla, Carlos Retamal, Mauricio A. Acuña, Rodrigo Sáez, Juan C. Regulation of Connexin-Based Channels by Fatty Acids |
title | Regulation of Connexin-Based Channels by Fatty Acids |
title_full | Regulation of Connexin-Based Channels by Fatty Acids |
title_fullStr | Regulation of Connexin-Based Channels by Fatty Acids |
title_full_unstemmed | Regulation of Connexin-Based Channels by Fatty Acids |
title_short | Regulation of Connexin-Based Channels by Fatty Acids |
title_sort | regulation of connexin-based channels by fatty acids |
topic | Physiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5258758/ https://www.ncbi.nlm.nih.gov/pubmed/28174541 http://dx.doi.org/10.3389/fphys.2017.00011 |
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