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Stochastic descriptors to study the fate and potential of naive T cell clonotypes in the periphery
The population of naive T cells in the periphery is best described by determining both its T cell receptor diversity, or number of clonotypes, and the sizes of its clonal subsets. In this paper, we make use of a previously introduced mathematical model of naive T cell homeostasis, to study the fate...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5258823/ https://www.ncbi.nlm.nih.gov/pubmed/27350044 http://dx.doi.org/10.1007/s00285-016-1020-6 |
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author | Artalejo, J. R. Gómez-Corral, A. López-García, M. Molina-París, C. |
author_facet | Artalejo, J. R. Gómez-Corral, A. López-García, M. Molina-París, C. |
author_sort | Artalejo, J. R. |
collection | PubMed |
description | The population of naive T cells in the periphery is best described by determining both its T cell receptor diversity, or number of clonotypes, and the sizes of its clonal subsets. In this paper, we make use of a previously introduced mathematical model of naive T cell homeostasis, to study the fate and potential of naive T cell clonotypes in the periphery. This is achieved by the introduction of several new stochastic descriptors for a given naive T cell clonotype, such as its maximum clonal size, the time to reach this maximum, the number of proliferation events required to reach this maximum, the rate of contraction of the clonotype during its way to extinction, as well as the time to a given number of proliferation events. Our results show that two fates can be identified for the dynamics of the clonotype: extinction in the short-term if the clonotype experiences too hostile a peripheral environment, or establishment in the periphery in the long-term. In this second case the probability mass function for the maximum clonal size is bimodal, with one mode near one and the other mode far away from it. Our model also indicates that the fate of a recent thymic emigrant (RTE) during its journey in the periphery has a clear stochastic component, where the probability of extinction cannot be neglected, even in a friendly but competitive environment. On the other hand, a greater deterministic behaviour can be expected in the potential size of the clonotype seeded by the RTE in the long-term, once it escapes extinction. |
format | Online Article Text |
id | pubmed-5258823 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-52588232017-02-13 Stochastic descriptors to study the fate and potential of naive T cell clonotypes in the periphery Artalejo, J. R. Gómez-Corral, A. López-García, M. Molina-París, C. J Math Biol Article The population of naive T cells in the periphery is best described by determining both its T cell receptor diversity, or number of clonotypes, and the sizes of its clonal subsets. In this paper, we make use of a previously introduced mathematical model of naive T cell homeostasis, to study the fate and potential of naive T cell clonotypes in the periphery. This is achieved by the introduction of several new stochastic descriptors for a given naive T cell clonotype, such as its maximum clonal size, the time to reach this maximum, the number of proliferation events required to reach this maximum, the rate of contraction of the clonotype during its way to extinction, as well as the time to a given number of proliferation events. Our results show that two fates can be identified for the dynamics of the clonotype: extinction in the short-term if the clonotype experiences too hostile a peripheral environment, or establishment in the periphery in the long-term. In this second case the probability mass function for the maximum clonal size is bimodal, with one mode near one and the other mode far away from it. Our model also indicates that the fate of a recent thymic emigrant (RTE) during its journey in the periphery has a clear stochastic component, where the probability of extinction cannot be neglected, even in a friendly but competitive environment. On the other hand, a greater deterministic behaviour can be expected in the potential size of the clonotype seeded by the RTE in the long-term, once it escapes extinction. Springer Berlin Heidelberg 2016-06-27 2017 /pmc/articles/PMC5258823/ /pubmed/27350044 http://dx.doi.org/10.1007/s00285-016-1020-6 Text en © The Author(s) 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
spellingShingle | Article Artalejo, J. R. Gómez-Corral, A. López-García, M. Molina-París, C. Stochastic descriptors to study the fate and potential of naive T cell clonotypes in the periphery |
title | Stochastic descriptors to study the fate and potential of naive T cell clonotypes in the periphery |
title_full | Stochastic descriptors to study the fate and potential of naive T cell clonotypes in the periphery |
title_fullStr | Stochastic descriptors to study the fate and potential of naive T cell clonotypes in the periphery |
title_full_unstemmed | Stochastic descriptors to study the fate and potential of naive T cell clonotypes in the periphery |
title_short | Stochastic descriptors to study the fate and potential of naive T cell clonotypes in the periphery |
title_sort | stochastic descriptors to study the fate and potential of naive t cell clonotypes in the periphery |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5258823/ https://www.ncbi.nlm.nih.gov/pubmed/27350044 http://dx.doi.org/10.1007/s00285-016-1020-6 |
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