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Bone health measured using quantitative ultrasonography in adult males with muscular dystrophy

OBJECTIVES: To compare muscle and bone health markers in adult males (aged 20-59 yrs) with and without muscular dystrophy (MD). METHODS: Participants included 11 Fascioscapulohumeral (FSH), 11 Becker’s (Be), 9 limb girdle (LG), 11 Duchenne (DMD), and 14 non-dystrophic controls (CTRL). Physical activ...

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Autores principales: Morse, C.I., Smith, J., Denny, A., Tweedale, J., Searle, N.D., Winwood, K., Onambele-Pearson, G.L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Society of Musculoskeletal and Neuronal Interactions 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5259575/
https://www.ncbi.nlm.nih.gov/pubmed/27973386
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author Morse, C.I.
Smith, J.
Denny, A.
Tweedale, J.
Searle, N.D.
Winwood, K.
Onambele-Pearson, G.L.
author_facet Morse, C.I.
Smith, J.
Denny, A.
Tweedale, J.
Searle, N.D.
Winwood, K.
Onambele-Pearson, G.L.
author_sort Morse, C.I.
collection PubMed
description OBJECTIVES: To compare muscle and bone health markers in adult males (aged 20-59 yrs) with and without muscular dystrophy (MD). METHODS: Participants included 11 Fascioscapulohumeral (FSH), 11 Becker’s (Be), 9 limb girdle (LG), 11 Duchenne (DMD), and 14 non-dystrophic controls (CTRL). Physical activity was assessed using Bone (BPAQ) and disability specific (PASIPD) questionnaires. Bone QUS provided T- and Z scores from the Distal Radius (DR) and Mid-shaft tibia (MST). Tibialis anterior cross sectional area (TA(ACSA)) was measured using B-mode ultrasound. Grip strength was measured in all but DMD. RESULTS: Physical activity was lower in DMD, FSH and BeMD than CTRL (P<0.05), and lower in DMD than other MDs (P<0.01). T and Z scores were lower in DMD and Be than CTRL (DR, P<0.05); and lower in DMD than CTRL, LG, and FSH (MST, P<0.01). TA(ACSA) and grip strength was 35-59% and 50-58% smaller in MD than CTRL, respectively (P<0.01). Within MD, BPAQ correlated with bone QUS measures (r=0.42-0.38, P<0.01). PASIPD correlated with grip strength (r=0.65, P<0.01) and TA(ACSA) (r=0.46, P<0.01). CONCLUSION: Muscle size, strength, and bone health was lower in adult males with MD compared to adult males without MD, the extent of this is partially determined by physical activity.
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spelling pubmed-52595752017-01-30 Bone health measured using quantitative ultrasonography in adult males with muscular dystrophy Morse, C.I. Smith, J. Denny, A. Tweedale, J. Searle, N.D. Winwood, K. Onambele-Pearson, G.L. J Musculoskelet Neuronal Interact Original Article OBJECTIVES: To compare muscle and bone health markers in adult males (aged 20-59 yrs) with and without muscular dystrophy (MD). METHODS: Participants included 11 Fascioscapulohumeral (FSH), 11 Becker’s (Be), 9 limb girdle (LG), 11 Duchenne (DMD), and 14 non-dystrophic controls (CTRL). Physical activity was assessed using Bone (BPAQ) and disability specific (PASIPD) questionnaires. Bone QUS provided T- and Z scores from the Distal Radius (DR) and Mid-shaft tibia (MST). Tibialis anterior cross sectional area (TA(ACSA)) was measured using B-mode ultrasound. Grip strength was measured in all but DMD. RESULTS: Physical activity was lower in DMD, FSH and BeMD than CTRL (P<0.05), and lower in DMD than other MDs (P<0.01). T and Z scores were lower in DMD and Be than CTRL (DR, P<0.05); and lower in DMD than CTRL, LG, and FSH (MST, P<0.01). TA(ACSA) and grip strength was 35-59% and 50-58% smaller in MD than CTRL, respectively (P<0.01). Within MD, BPAQ correlated with bone QUS measures (r=0.42-0.38, P<0.01). PASIPD correlated with grip strength (r=0.65, P<0.01) and TA(ACSA) (r=0.46, P<0.01). CONCLUSION: Muscle size, strength, and bone health was lower in adult males with MD compared to adult males without MD, the extent of this is partially determined by physical activity. International Society of Musculoskeletal and Neuronal Interactions 2016-12 /pmc/articles/PMC5259575/ /pubmed/27973386 Text en Copyright: © Journal of Musculoskeletal and Neuronal Interactions http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Morse, C.I.
Smith, J.
Denny, A.
Tweedale, J.
Searle, N.D.
Winwood, K.
Onambele-Pearson, G.L.
Bone health measured using quantitative ultrasonography in adult males with muscular dystrophy
title Bone health measured using quantitative ultrasonography in adult males with muscular dystrophy
title_full Bone health measured using quantitative ultrasonography in adult males with muscular dystrophy
title_fullStr Bone health measured using quantitative ultrasonography in adult males with muscular dystrophy
title_full_unstemmed Bone health measured using quantitative ultrasonography in adult males with muscular dystrophy
title_short Bone health measured using quantitative ultrasonography in adult males with muscular dystrophy
title_sort bone health measured using quantitative ultrasonography in adult males with muscular dystrophy
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5259575/
https://www.ncbi.nlm.nih.gov/pubmed/27973386
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